Israeli fertility experts call for international chromosome registry


All 65 of the couples in the study had either suffered more than six unsuccessful embryo transfers or cumulative transfers of more than 15 embryos. They underwent genetic screening as well as other investigations and this revealed a variety of abnormalities in 16 of the women and two of the partners. One woman out of 16 did give birth, a second has an ongoing pregnancy but the other 14 never conceived, had miscarriages or, in one case, had only immature eggs.

Dr Raziel said that other studies had shown that the prevalence of chromosomal abnormalities in infertile men ranged from 2% to 14%, and identifying abnormalities in the partners of two of the 16 women demonstrated that both partners in a fraction of couples will have problems.

He told the conference: "We recommend that for women who suffer repeated implantation failure after IVF, peripheral blood karyotyping should be part of the routine work-up of the couple. Treatment can then be tailored to fit the individual patient's gynaecological background and the type of chromosomal changes detected. That treatment may be pre-implantation genetic diagnosis, further attempts at IVF or oocyte donation when an egg factor is involved."


Contact: Margaret Willson
European Society for Human Reproduction and Embryology

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