HOME >> BIOLOGY >> NEWS
Israeli scientists reveal the plan of a key cellular machine

A team of scientists from the Weizmann Institute of Science and the Hebrew University of Jerusalem has revealed the structure of a cellular editor that "cuts and pastes" the first draft of RNA straight after it is formed from its DNA template. Many diseases appear to be tied to mistakes in this process, and understanding the workings of the machinery involved may lead to the ability to correct or prevent them in the future.

Since the discovery, around 25 years ago, that the bits of DNA in the genes that code for protein formation are interspersed with "filler" segments that have no known function, scientists have worked to understand the process by which the right sequences are lifted out and strung together to make a coherent set of instructions. This act, referred to as "RNA splicing," takes place in the "spliceosome" situated in the cell nucleus. A large complex of proteins and short strands of RNA, the spliceosome distinguishes the beginnings and ends of coded segments, precisely cutting and stitching them together. Alternative splicing, which underlies the huge diversity of proteins in the body by allowing segments of the genetic code to be strung together in different ways, takes place in the spliceosome as well.

The team consisted of husband-and-wife scientists Prof. Ruth Sperling of the Genetics department of the Hebrew University and Prof. Joseph Sperling of the Organic Chemistry Department of the Weizmann Institute, Ruth's graduate student Maia Azubel, and Sharon Wolf of the Chemical Research Support Department at the Institute. They produced the most detailed 3-D representation of the spliceosome's structure to date with their study, published today in Molecular Cell.

Rather than follow previous attempts to unravel the workings of the splicing mechanism by studying spliceosomes created in test tubes, they managed to take spliceosomes directly from living cells and examine them under an electron microscope.

Their task
'"/>

Contact: Alex Smith
asmith@jgordanassociates.com
212-367-3892
American Committee for the Weizmann Institute of Science
9-Sep-2004


Page: 1 2 3

Related biology news :

1. Study by Israeli scientists provides insight on DNA code
2. Scientists identify a gene causing a fatal heart condition, common in an Israeli Bedouin tribe
3. Israeli scientists block the progression of Type I diabetes
4. Israeli scientists discover gene responsible for hereditary muscle disease prevalent among Jews of Persian descent
5. Israeli teams grows heart cells and insulin producing cells from human embryonic stem cells
6. Israeli fertility experts call for international chromosome registry
7. Dr. Robert C. Gallo to Collaborate with Visiting Israeli Scientist on Promising HIV Vaccine Research at Marylands Institute of Human Virology
8. Researchers develop white wine with cholesterol-lowering benefits, discover Israeli wines healthier than French wines
9. Hopkins, Israeli Scientists Link Soybeans With Pain Relief
10. DNA lends scientists a hand, revealing new chemical reactions
11. Conference at UH opens doors for new scientists, engineers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2019)... ... ... Lajollacooks4u is delighted to announce it has been named as one of ... only to businesses that have achieved consistently outstanding traveler reviews on TripAdvisor, as well ... qualify for the Certificate of Excellence –- an award that only 10 percent of ...
(Date:5/31/2019)... ... May 29, 2019 , ... ... Windows and mobile, announces the launch of version 13.1. The new version extends ... Management API, and supports Apple’s spring release functionality. Version 13.1 builds on FileWave’s ...
(Date:5/31/2019)... Kan. (PRWEB) , ... May 30, 2019 , ... Enso ... year, and especially during Military Appreciation Month, as a way to express his gratitude ... Patrick, and the company he founded — Enso Discoveries — presented a ...
Breaking Biology News(10 mins):
(Date:6/12/2019)... ... June 12, 2019 , ... Leak Detection ... for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries, is excited to ... agreement will grant exclusive rights for Zillion to represent LDA in all of ...
(Date:6/11/2019)... ... June 10, 2019 , ... DeepDyve and ... journals to DeepDyve’s rental service for peer-reviewed journals. , IOPP’s portfolio represents ... than 20 million articles, sourced from more than 15,000 journals. , “By partnering ...
(Date:6/11/2019)... ... June 11, 2019 , ... A study released today in ... are able to incorporate into human CD34+ cells, modifying their gene expression and ... increased the cells’ ability to lodge into bone marrow. This research performed by ...
(Date:5/31/2019)... City, California (PRWEB) , ... ... ... allowance of our patent applications from the USPTO providing proprietary interest to ... AND METHOD FOR SLEEP DISORDER DIAGNOSIS AND TREATMENT… extends Somnology’s IP rights ...
Breaking Biology Technology:
Cached News: