HOME >> BIOLOGY >> NEWS
Israeli scientists reveal the plan of a key cellular machine

was made difficult by the fact that spliceosomes in living cells are made up of four identical modules strung together like beads on a strand of RNA, each a miniature spliceosome capable of splicing on its own. The connections between the modules tend to be flexible, allowing the position of the units to vary in relation to each other. Thus pinning down a definitive shape and structure for the whole complex has been, until now, nearly impossible.

The team found a way to cut the RNA connections between the modules without harming the integral short strands of RNA that are essential to the splicing process, so they could study them individually. Split-second freezing at very low temperatures allowed the scientists to view the spliceosome units in as close to a natural state as possible. From thousands of images, each at a slightly different angle, a composite 3-D structure of the spliceosome was built up.

The revealed structure has two distinct, unequal halves surrounding a tunnel. The larger part appears to contain proteins and the short segments of RNA, while the smaller half is made up of proteins alone. On one side, the tunnel opens up into a cavity, which the researchers think functions as a holding space for the fragile RNA waiting to be processed in the tunnel itself.

What they didn't see may be as important as what they saw. Whereas researchers examining splicing in test tubes saw evidence of a complicated sequence of events in which the spliceosome machinery assembles itself anew for each splicing job, the team's investigations of spliceosomes from live cells found splicing to take place in pre-formed machines. This fits in with what is known about the way cells optimize their workload. "It's much more efficient to have a machine on hand, ready to go, than to build a new one each time," they noted.

Prof. Sperling's research is supported by the Joseph and Ceil Mazer Center for Structural Biology, the Helen and Milton A. Ki
'"/>

Contact: Alex Smith
asmith@jgordanassociates.com
212-367-3892
American Committee for the Weizmann Institute of Science
9-Sep-2004


Page: 1 2 3

Related biology news :

1. Study by Israeli scientists provides insight on DNA code
2. Scientists identify a gene causing a fatal heart condition, common in an Israeli Bedouin tribe
3. Israeli scientists block the progression of Type I diabetes
4. Israeli scientists discover gene responsible for hereditary muscle disease prevalent among Jews of Persian descent
5. Israeli teams grows heart cells and insulin producing cells from human embryonic stem cells
6. Israeli fertility experts call for international chromosome registry
7. Dr. Robert C. Gallo to Collaborate with Visiting Israeli Scientist on Promising HIV Vaccine Research at Marylands Institute of Human Virology
8. Researchers develop white wine with cholesterol-lowering benefits, discover Israeli wines healthier than French wines
9. Hopkins, Israeli Scientists Link Soybeans With Pain Relief
10. DNA lends scientists a hand, revealing new chemical reactions
11. Conference at UH opens doors for new scientists, engineers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2020)... Mass. (PRWEB) , ... June 24, 2020 , ... ... of cloud-based enterprise software and software-driven clinical data services that accelerate drug development, ... for low-dose selinexor, an XPO1 inhibitor, in hospitalized patients with severe COVID-19. This ...
(Date:6/23/2020)... ... June 22, 2020 , ... The field of quantitation of ... assays (LBA) have dominated this area. However, the use of mass spectrometry in this ... now necessitates the question “How do you choose which approach to use (LBA or ...
(Date:6/19/2020)... (PRWEB) , ... June 16, 2020 , ... The director ... is betting that if the stem cell medicine and pharmaceutical industries have easier access ... practice. So, starting July 5 of this year, Independence Day weekend in the ...
Breaking Biology News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... Slone ... companies, has announced the placement of Julianne Averill , CPA, as Chief ... all financial operations and implementing key business strategies to accelerate Alveo’s growth as ...
(Date:8/12/2020)... ... August 11, 2020 , ... ... cold chain validation engineering firm, is making available for free its new ... to incorporate concurrent transport simulation testing into today’s biologics licensing application (BLA). ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been touted as ... cover the history of eSource, the reasons it did not take off as quickly ... site source, the industry is moving towards capturing data electronically for clinical trials and ...
Breaking Biology Technology:
Cached News: