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JCI Table of Contents, 15 August 2003

ium and potassium balance

AUTHOR CONTACT:
Bernard C. Rossier
Institut de Pharmacologie et de Toxicologie, Lausanne, Switzerland.
Phone: 41-21-692-5351
Fax: 41-21-692-5355
E-mail: bernard.rossier@ipharm.unil.ch

View the PDF of this article at: https://www.the-jci.org/press/16956.pdf

Signaling interplay during inflammation

Interferon-gamma (IFN-gamma) plays a central role in controlling the host immune response, however the precise mechanisms contributing to this control have not been fully defined. Nicholas Topley and colleagues from the University of Wales College of Medicine utilized a mouse model of acute peritnoneal inflammation in order to demonstrate that IFN-gamma directly controls the infiltration of neutrophils to the site of infection and modulates interleukin-6 (IL-6) signaling through its soluble receptor (sIL-6R) in order to promote clearance of foreign invaders and resolve inflammation. This study adds to our understanding of acute inflammatory states and should aid in determining suitable therapeutic strategies.

TITLE: Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation

AUTHOR CONTACT:
Nicholas Topley
University of Wales College of Medicine, Cardiff, United Kingdom.
Phone: 44-29-20748432
Fax: 44-29-20748470
E-mail: topley@cf.ac.uk

View the PDF of this article at: https://www.the-jci.org/press/17129.pdf

MOG: a minor myelin protein, a major self-antigen

Myelin/oligodendrocyte glycoprotein (MOG) is a minor protein component of myelin, which provides a insulating sheath around neurons. MOG is involved in diseases suc
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Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
15-Aug-2003


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