cer progression through the inhibition of the tumor supressing effects of Activin. In an accompanying commentary, Michael Shen from the University of Medicine and Dentistry in Piscataway, New Jersey, discusses some of the proposed mechanisms of this inhibition. "The exciting finding that antibody blockade of Cripto has a strong effect in xenograft models indicates that Cripto functions in a central pathway for cell proliferation and/or maintenance of the transformed state. While much more analysis is needed to decode the molecular mechanisms of Cripto function, the work now provides a glimmer of understanding as to the functions of this enigmatic protein in tumorigenesis".
TITLE: Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo
AUTHOR CONTACT:
Michele Sanicola
Biogen Inc., Cambridge, Massachusetts, USA.
Phone: (617) 679-3307
Fax: (617) 914-7140
E-mail: michele_sanicola@biogen.com
View the PDF of this article at: https://www.the-jci.org/press/17788.pdf
ACCOMPANING COMMENTARY:
Decrypting the role of Cripto in tumorigenesis
AUTHOR CONTACT:
Michael M. Shen
Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey, USA.
Phone: (732) 235-5645
Fax: (732) 235-5373
Email: mshen@cabm.rutgers.edu
View the PDF of this commentary at: https://www.the-jci.org/press/19546.pdf
Arresting asthma
Asthma, a complex inflammatory disease afflicting nearly 15 million Americans, is mediated by Th2 cells. Migration of Th2 cells to the lung is key to their inflammatory function and is regulated in large part by chemokine receptors. Robert Lefkowitz and colleagues from Duke University Medical Cen
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Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
15-Aug-2003
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