HOME >> BIOLOGY >> NEWS
JCI Table of Contents, 15 August 2003

(known as EMT), the process of transformation from epithelial cells to matrix-producing fibroblasts, that may ultimately result in renal interstitial fibrosis and renal failure. EMT is regulated by numerous hormones and growth factors, including tumor growth factor beta1 (TGF-beta1). Youhua Liu and colleagues from the University of Pittsburgh School of Medicine demonstrate that expression of the intracellular enzyme integrin-linked kinase (ILK) is specifically induced in renal tubular epithelial cells in response to TGFbeta1 and that ILK administration induces many key events in TGFbeta1-induced EMT. The data implicate ILK as a crucial mediator of EMT in renal interstitial fibrosis. The authors demonstrate that administration of a kinase-dead form of ILK abolishes TGFbeta1-induced EMT suggesting that this and other inhibitors of ILK signaling could be explored as potential therapies for chronic renal disease.

TITLE: Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis

AUTHOR CONTACT:
Youhua Liu
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Phone: (412) 648-8263
Fax: (412) 648-1916
E-mail: liuy@msx.upmc.edu

View the PDF of this article at: https://www.the-jci.org/press/17913.pdf


Interfering interferons in medulloblastoma

Type I interferons (IFN-alpha and IFN-beta), crucial for fighting viral infection and regulating immune function, signal via activation of STAT1 and STAT2. Iain Campbell and colleagues from the Scripps Institute in La Jolla, California, show that in mice lacking STAT2, IFN-alpha retains potent biological activity in the central nervous system. IFN-alpha mediates a type Ilike immune response with IFN-gamma gene expression and signaling in the brain associated wit
'"/>

Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
15-Aug-2003


Page: 1 2 3 4 5 6 7 8 9 10 11 12

Related biology news :

1. JCI Table of Contents, 15 July 2004
2. JCI Table of Contents, January 15 2004
3. JCI Table of Contents, November 3, 2003
4. JCI Table of Contents, 1 October, 2003
5. JCI Table of Contents, September 15, 2003
6. JCI Table of Contents
7. JCI Table of Contents, May 1, 2003
8. JCI Table of Contents, April 1, 2003
9. JCI Table of Contents, March 14, 2003
10. JCI Table of Contents, January 2, 2003
11. JCI Table of Contents, December 2, 2002

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2016)... , Feb. 2, 2016   Parabon ... from the U.S. Army Research Office and the ... range and sensitivity of the company,s Snapshot ... Accounting Mission and, more generally, defense-related DNA forensics. ... phenotyping capabilities (predicting appearance and ancestry from DNA ...
(Date:1/28/2016)... 2016 Synaptics (NASDAQ: SYNA ), a leading developer ... quarter ended December 31, 2015. --> ... 2016 increased 2 percent compared to the comparable quarter last year ... 2016 was $35.0 million, or $0.93 per diluted share. ... the first quarter of fiscal 2016 grew 9 percent over the ...
(Date:1/22/2016)... , Jan. 22, 2016 ... addition of the "Global Biometrics Market ... their offering. --> http://www.researchandmarkets.com/research/p74whf/global_biometrics ... "Global Biometrics Market in Retail Sector ... --> Research and Markets ( ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... -- Vermillion, Inc. (NASDAQ: VRML ), a bio-analytical solutions ... of the Steering Committee for its Pelvic Mass Registry. ... Pelvic masses can present physicians and healthcare professionals with ... ruled out, pelvic masses may include cancers of the ... tumors and gastrointestinal and urinary tract masses. ...
(Date:2/11/2016)... Feb. 11, 2016  Wellcentive today announced it ... Portland, Oregon -based community care organization (CCO) ... health analytics, quality reporting and care management solutions ... its team of quality managers, analysts and care ... provider groups serving FamilyCare members. ...
(Date:2/11/2016)... , Feb. 11, 2016   BioInformant ... report, "Stem Cell Research Products, Opportunities, Tools, and Technologies ... ... in the stem cell industry, BioInformant has more than ... the stem cell market, by stem cell type. This ...
(Date:2/10/2016)... 2016 /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ), ... that Mitsui & Co. Ltd., its partner in the ... is investing an additional CDN$25 million in the joint ... from 30% to 40%.  Mitsui will also play a ... in Sarnia , providing dedicated resources ...
Breaking Biology Technology:
Cached News: