HOME >> BIOLOGY >> NEWS
JCI Table of Contents, 15 August 2003

(known as EMT), the process of transformation from epithelial cells to matrix-producing fibroblasts, that may ultimately result in renal interstitial fibrosis and renal failure. EMT is regulated by numerous hormones and growth factors, including tumor growth factor beta1 (TGF-beta1). Youhua Liu and colleagues from the University of Pittsburgh School of Medicine demonstrate that expression of the intracellular enzyme integrin-linked kinase (ILK) is specifically induced in renal tubular epithelial cells in response to TGFbeta1 and that ILK administration induces many key events in TGFbeta1-induced EMT. The data implicate ILK as a crucial mediator of EMT in renal interstitial fibrosis. The authors demonstrate that administration of a kinase-dead form of ILK abolishes TGFbeta1-induced EMT suggesting that this and other inhibitors of ILK signaling could be explored as potential therapies for chronic renal disease.

TITLE: Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis

AUTHOR CONTACT:
Youhua Liu
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Phone: (412) 648-8263
Fax: (412) 648-1916
E-mail: liuy@msx.upmc.edu

View the PDF of this article at: https://www.the-jci.org/press/17913.pdf


Interfering interferons in medulloblastoma

Type I interferons (IFN-alpha and IFN-beta), crucial for fighting viral infection and regulating immune function, signal via activation of STAT1 and STAT2. Iain Campbell and colleagues from the Scripps Institute in La Jolla, California, show that in mice lacking STAT2, IFN-alpha retains potent biological activity in the central nervous system. IFN-alpha mediates a type Ilike immune response with IFN-gamma gene expression and signaling in the brain associated wit
'"/>

Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
15-Aug-2003


Page: 1 2 3 4 5 6 7 8 9 10 11 12

Related biology news :

1. JCI Table of Contents, 15 July 2004
2. JCI Table of Contents, January 15 2004
3. JCI Table of Contents, November 3, 2003
4. JCI Table of Contents, 1 October, 2003
5. JCI Table of Contents, September 15, 2003
6. JCI Table of Contents
7. JCI Table of Contents, May 1, 2003
8. JCI Table of Contents, April 1, 2003
9. JCI Table of Contents, March 14, 2003
10. JCI Table of Contents, January 2, 2003
11. JCI Table of Contents, December 2, 2002

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: JCI Table Contents August

(Date:11/4/2014)... LAKE CITY, Nov. 5, 2014 – University of Utah ... enzymes to help jet fuel produce electricity without needing ... be used to power portable electronics, off-grid power and ... online today in the American Chemical Society journal ... electricity through a chemical reaction between a fuel and ...
(Date:11/4/2014)... PA) – Temple University School of Medicine announced ... winner, an initiative funded by the Bill & ... Professor of Obstetrics, Gynecology and Reproductive Sciences; and ... Temple University School of Medicine will pursue an ... "Maternal Blood Biomarkers to Assess Fetal Neurodevelopment.", Grand ...
(Date:11/4/2014)... A newly published research study examining only marketing ... of fast food restaurants has found that the ... disproportionately exposed to such marketing tactics. , Authored ... her colleagues, the study is the first to ... interior and exterior of fast food restaurants and ...
Breaking Biology News(10 mins):Jet-fueled electricity at room temperature 2Temple University School of Medicine receives Grand Challenges Explorations grant 2Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3
(Date:11/24/2014)... 24, 2014 2014 Deep Research ... is a professional and in-depth research report on ... information, like its definition, classification, application, and industry ... report covers the international market analysis, including China’s ... the US, Europe, Asia, China, Japan etc. regions) ...
(Date:11/24/2014)... , Nov. 24, 2014  Spherix Incorporated ... company committed to the fostering and monetization of ... v. VTech Telecommunications Ltd.,  Case No. 3:13-cv-03494-M and  ... No. 3:13-cv-03496-M, both in the United States District ... Texas . On November ...
(Date:11/23/2014)... Apiscent Labs, a privately held ... ingredients to the global pharmaceutical and flavor & ... website, Apiscent.com. , The Apiscent.com homepage welcomes visitors ... easy navigation, rotating images and content focused on ... , The company’s work in Pharmaceutical ...
(Date:11/22/2014)... (PRWEB) November 21, 2014 During his ... understood the need to surround himself with great people ... and entrepreneur, his friends often marveled at his extraordinarily ... lived his life and -- even with his death ... the Alzheimer’s disease that would ultimately take his life. ...
Breaking Biology Technology:Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 2Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 3Markman Hearing Held as Scheduled in VTech and Uniden Cases 2Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 2Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 3
Cached News: