TITLE: Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-alphastimulated STAT2-independent production of IFN-gamma in the brain
AUTHOR CONTACT:
Iain L. Campbell
The Scripps Research Institute, La Jolla, California, USA.
Phone: (858) 784-9306
Fax: (858) 784-9544
E-mail: icamp@scripps.edu
View the PDF of this article at: https://www.the-jci.org/press/18637.pdf
Thyroid hormones in a binding contract
Thyroid hormones are critical for differentiation, growth, and metabolism. Thyroid hormone receptor beta (TRbeta) has been implicated in the development of both auditory and visual systems. Interested in the biological role of TRbeta, Fredric Wondisford and colleagues from the University of Chicago have demonstrated that DNA binding is critical for most functions of this receptor. Their study also suggests that novel mechanisms independent of DNA binding may contribute to the regulation of auditory function by TRbeta. In his accompanying commentary Mitchell Lazar from the University of Pennsylvania School of Medicine discusses alternative mechanisms whereby thyroid hormones can regulate gene expression in a manner that does not involve binding to DNA.
TITLE: Thyroid hormo
'"/>
Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
15-Aug-2003