JCI Table of Contents, 15 A...( h the development of medulloblastoma t...)

h the development of medulloblastoma, the most common type of brain tumor. Further, the authors show that the Sonic hedgehog (Shh) signaling pathway, which is implicated in the development of medulloblastoma, is activated in granule neurons, and this process can be mediated by IFN-gamma. These findings show the dire consequences of STAT2-independent type I IFN signaling and reveal a previously unknown link between the immune system and the pathogenesis of developmental disorders and tumorigenesis of the central nervous system due to dysregulated Shh signaling mediated by IFN-gamma.

TITLE: Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-alphastimulated STAT2-independent production of IFN-gamma in the brain

AUTHOR CONTACT:
Iain L. Campbell
The Scripps Research Institute, La Jolla, California, USA.
Phone: (858) 784-9306
Fax: (858) 784-9544
E-mail: icamp@scripps.edu

View the PDF of this article at: https://www.the-jci.org/press/18637.pdf

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Thyroid hormones in a binding contract

Thyroid hormones are critical for differentiation, growth, and metabolism. Thyroid hormone receptor beta (TRbeta) has been implicated in the development of both auditory and visual systems. Interested in the biological role of TRbeta, Fredric Wondisford and colleagues from the University of Chicago have demonstrated that DNA binding is critical for most functions of this receptor. Their study also suggests that novel mechanisms independent of DNA binding may contribute to the regulation of auditory function by TRbeta. In his accompanying commentary Mitchell Lazar from the University of Pennsylvania School of Medicine discusses alternative mechanisms whereby thyroid hormones can regulate gene expression in a manner that does not involve binding to DNA.

TITLE: Thyroid hormo
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Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
15-Aug-2003

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