JCI Table of Contents, 15 July 2004

Stem Cells Get a Workout
Female Infertility camp
Getting to the HAART of Bone Loss
ApoA-IV has the Guts to Fight Inflammation
Not by Mutation Identification Alone

Fat Gets Cut Away from Insulin Resistance
Pulmonary Fibrosis Polarized by Cytokines
Anuerysms in Allografted aorta
IDO says Don't to Asthma
IDO Can Do Anergy
HCV Mutation Impairs T Cell Inductionb
Noncanonical Insulin Target Tissues in Diabetes


Stem Cells Get a Workout

Muscular dystrophies are characterized by severe muscle damage, ultimately through the loss of the ability to regenerate muscle. Generating alternative sources for precursor cells to replenish muscle fibers offers a potential therapeutic strategy to treat myopathies. Yvan Torrente and colleagues, from the University of Milan, having previously shown that a cellular marker called AC133 is required for muscle precursor cells to differentiate into mature muscle, the researchers now demonstrate that AC133-positive stem cells are a promising new source for replenishing muscle satellite cells that are depleted in muscular dystrophies. The researchers isolated human AC133-positive stem cells from normal blood. After growth in culture, these cells were subsequently injected into the skeletal muscle tissue of mice that are a model for human Duchene muscular dystrophy. The human stem cells invaded the damaged muscle fibers, expressed muscle fiber markers, and formed functional myofibers that restored muscle function. The injected mice also experienced amelioration of the clinical symptoms of muscular dystrophy and a restoration of the satellite cell pool required for muscle regeneration. This study provides new leads in the treatment of these debilitating muscle diseases.

TITLE: Human circulating A

Contact: Laurie Goodman
Journal of Clinical Investigation

Page: 1 2 3 4 5 6 7 8 9 10

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