JCI Table of Contents, April 1, 2003

eting B cells. This suggests that interaction between CCR10 and its mucosal epithelial ligand MEC may form the basis for a homing mechanism that guides the specific dissemination of IgA-secreting B cells after local immunization.

Eric Kunkel
Bioseek, Inc.
863-C Mitten Rd.
Burlingame, CA 94010
Phone 1-650-231-1251
Fax 1-650-552-0725
E-mail: ekunkel@bioseekinc.com

View the PDF of this article at:

Atopy-Promoting Dendritic Cells
The gamma chain of the high-affinity IgE receptor (FceRIgamma) is selectively expressed on antigen-presenting cells from atopic individuals and has been implicated in the pathophysiology of atopic diseases. Interested in the regulation of this receptor on DCs, Thomas Bieber and colleagues have examined the expression of the different components of the receptor during DC maturation (pages 10471056). While FceRIapha is present at high levels throughout DC development in atopic and nonatopic individuals, expression of FceRIgamma, which is essential for surface expression of the multimeric receptor, is normally downregulated upon DC differentiation. DCs from atopic individuals, however, show significant levels of FceRIgamma expression, and express the receptor on the surface of mature DCs. In addition to established anti-IgE treatments, modulation of FceRIgamma expression in DCs might prove useful in the management of atopic diseases.


Thomas Bieber
University of Bonn
Department of Dermatology
Sigmund Freud Str. 25
53105 Bonn,
Phone: 1-49-228-287-4388
Fax: 1-49-228-287-4881
E-mail: thomas.bieber@ukb.uni-bonn.de

View the PDF of

Contact: Brooke Grindlinger
Journal of Clinical Investigation

Page: 1 2 3 4 5 6 7 8

Related biology news :

1. JCI Table of Contents, 15 July 2004
2. JCI Table of Contents, January 15 2004
3. JCI Table of Contents, November 3, 2003
4. JCI Table of Contents, 1 October, 2003
5. JCI Table of Contents, September 15, 2003
6. JCI Table of Contents
7. JCI Table of Contents, 15 August 2003
8. JCI Table of Contents, May 1, 2003
9. JCI Table of Contents, March 14, 2003
10. JCI Table of Contents, January 2, 2003
11. JCI Table of Contents, December 2, 2002

Post Your Comments:

(Date:5/31/2019)... ... 29, 2019 , ... FileWave, the multi-platform endpoint management solution ... of version 13.1. The new version extends FileWave’s mobile device management features on ... release functionality. Version 13.1 builds on FileWave’s version 13 that was released in ...
(Date:5/31/2019)... ... ... Enso Discoveries Chief Executive Officer, Patrick Farley, is honored to give back to ... his gratitude and respect for those who have served their country. In honor of ... presented a check for $1,000 to the Green Beret Foundation, via former US Army ...
(Date:5/24/2019)... WOODLANDS, Texas (PRWEB) , ... May 24, 2019 , ... ... been published and is now available on the company’s global website. , Crystallography Times ... on single crystal X-ray diffraction. It serves the X-ray analysis community by presenting the ...
Breaking Biology News(10 mins):
(Date:5/2/2019)... , ... May 02, 2019 , ... Stay on top ... medical device and food industries. Access to all webinars is free, so be sure ... in your field! , Visit http://www.xtalks.com to see our upcoming webinars: , ...
(Date:4/25/2019)... ... , ... Frank is an albino, deaf Great Dane. His owners rescued him when he was ... issues. Despite his hearing impairment, he was always an active and playful pup. Frank bonded ... every day. As the two grew, playtime became rougher and Frank ended up injuring his ...
(Date:4/16/2019)... ... April 16, 2019 , ... ... their project partner, the U.S. Army Center for Environmental Health Research (USACEHR), with ... Combined In-Licensing/Out-Licensing.” , Blue Sources, a veteran-owned company located at the Frederick Innovative ...
(Date:4/12/2019)... , ... April 12, 2019 , ... ... developments in neurotechnology and will educate about innovative tools and devices being used ... local listings for more information. , This segment of Advancements will focus on ...
Breaking Biology Technology:
Cached News: