JCI Table of Contents, April 1, 2003

eting B cells. This suggests that interaction between CCR10 and its mucosal epithelial ligand MEC may form the basis for a homing mechanism that guides the specific dissemination of IgA-secreting B cells after local immunization.

Eric Kunkel
Bioseek, Inc.
863-C Mitten Rd.
Burlingame, CA 94010
Phone 1-650-231-1251
Fax 1-650-552-0725
E-mail: ekunkel@bioseekinc.com

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Atopy-Promoting Dendritic Cells
The gamma chain of the high-affinity IgE receptor (FceRIgamma) is selectively expressed on antigen-presenting cells from atopic individuals and has been implicated in the pathophysiology of atopic diseases. Interested in the regulation of this receptor on DCs, Thomas Bieber and colleagues have examined the expression of the different components of the receptor during DC maturation (pages 10471056). While FceRIapha is present at high levels throughout DC development in atopic and nonatopic individuals, expression of FceRIgamma, which is essential for surface expression of the multimeric receptor, is normally downregulated upon DC differentiation. DCs from atopic individuals, however, show significant levels of FceRIgamma expression, and express the receptor on the surface of mature DCs. In addition to established anti-IgE treatments, modulation of FceRIgamma expression in DCs might prove useful in the management of atopic diseases.


Thomas Bieber
University of Bonn
Department of Dermatology
Sigmund Freud Str. 25
53105 Bonn,
Phone: 1-49-228-287-4388
Fax: 1-49-228-287-4881
E-mail: thomas.bieber@ukb.uni-bonn.de

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Contact: Brooke Grindlinger
Journal of Clinical Investigation

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