JCI Table of Contents, April 1, 2003

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PTEN: A New Player in Allergen-Induced Inflammation
Eosinophil accumulation and activation are important events in the development of asthma and involve the enzyme PI3K. The phosphatase PTEN, a major player in cell survival signaling, is known to oppose the action of PI3K. Interested in the role of PTEN in bronchial asthma, Yong Lee and colleagues studied the effects of PI3K inhibitors and PTEN in a mouse model of allergen-induced bronchial inflammation and airway hyperresponsiveness. On pages 10831092 the authors show that PTEN expression is diminished in airway epithelial cells of antigen-sensitized and -challenged mice. Intratracheal administration of PI3K inhibitors or adenovirus carrying PTEN cDNA remarkably reduced eosinophil levels and inflammation. One likely mechanism for this reduction is PTEN-mediated eosinophil degranulation and suppression of IL-4 and IL-5. The data support the potential use of PTEN or other PI3K inhibitors for the regulation of allergic inflammation.

Yong Chul Lee
Chonbuk National University Medical School
Department of Internal Medicine
634-18 Keumamdong
Chonju 561-712,
Phone: 1-8263-250-1664
Fax: 1-8263-254-1609
E-mail: leeyc@moak.chonbuk.ac.kr

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Neuronal and Inflammatory Cell Interplay During Lung Injury
Neurogenic inflammation -- the initiation or amplification of the inflammatory response to noxious stimuli by injured or irritated sensory nerves -- is mediated by PPT-A geneencoded neurokinins stored primarily in unmyelinated nerve fibers. Recent reports have also indicat

Contact: Brooke Grindlinger
Journal of Clinical Investigation

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