JCI Table of Contents, December 2, 2002

**Please mention the Journal of Clinical Investigation as the source of these articles**

Find below two highlighted articles and the full Table of Contents for the December 2, 2002 issue


Restoration of Faulty Blood Vessel Architecture by Angiopoietin-1

Angiogenesis (the growth of new blood vessels) requires complex signaling between multiple cell types, and abnormalities in these pathways results in faulty vessels. During normal vessel formation endothelial cells that comprise the blood vessel communicate, through a number of secreted agents called growth factors, with a family of cells known as mural cells. Endothelial cells secrete the growth factor PDGF B that is bound to mural cells by the PDGF-b receptor. Murals cells are then recruited to the new vessel where upon direct interaction with endothelial cells they secrete angiopoietin-1 (Ang1). Multiple roles in vessel maturation have been designated to Ang1 and they include sprouting, survival and stability of the new vessel. However, the exact nature of its involvement is unclear. The critical interactions between endothelial cells and mural cells facilitate the growth and maturation of new blood vessels. In diseases such as diabetic retinopathy, mural cells are absent from the vessel maturation process, which results in abnormal vessels growing on top of the retina, which can lead to blindness. The complex mechanisms by which mural cells regulate the activity of endothelial cells is also unclear. One way to investigate this relationship would be to develop an experimental system in which mural cells and endothelial cells are separated, yet new blood vessels still develop. As this development usually happens in the early embryo, it has been a difficult experimental system to manipulate. In the December 2 issue of the Journal of Clinical Investigation, Akiyoshi Uemura a

Contact: Brooke Grindlinger, PhD
Journal of Clinical Investigation

Page: 1 2 3 4 5 6 7 8 9 10 11 12

Related biology news :

1. JCI Table of Contents, 15 July 2004
2. JCI Table of Contents, January 15 2004
3. JCI Table of Contents, November 3, 2003
4. JCI Table of Contents, 1 October, 2003
5. JCI Table of Contents, September 15, 2003
6. JCI Table of Contents
7. JCI Table of Contents, 15 August 2003
8. JCI Table of Contents, May 1, 2003
9. JCI Table of Contents, April 1, 2003
10. JCI Table of Contents, March 14, 2003
11. JCI Table of Contents, January 2, 2003

Post Your Comments:

(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 2017 The Controller General of Immigration from Maldives ... Algeen have received the prestigious international IAIR Award for the most ... Reading ... Maldives ... Abdulla Algeen (small picture on the right) have received the IAIR award ...
(Date:3/23/2017)... PUNE, India , March 23, 2017 The report ... Equipment, Touchless Biometric), Industry, and Geography - Global Forecast to 2022", published by ... growing at a CAGR of 29.63% between 2017 and 2022. ... ... Logo ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... N.C. (PRWEB) , ... October 11, 2017 , ... ... ARCS® Foundation President Andi Purple announced Dr. Suneel I. Sheikh, the co-founder, ... ( ASTER Labs ), Inc. has been selected for membership in ARCS ...
(Date:10/11/2017)... ... 2017 , ... Proscia Inc ., a data solutions ... “Pathology is going digital. Is your lab ready?” with Dr. Nicolas Cacciabeve, Managing ... how Proscia improves lab economics and realizes an increase in diagnostic confidence.* ...
(Date:10/11/2017)... (PRWEB) , ... October 11, 2017 , ... ... compared the implantation and pregnancy rates in frozen and fresh in vitro ... of progesterone and maternal age to IVF success. , After comparing the results ...
(Date:10/10/2017)... ... 2017 , ... For the second time in three years, ... Award. Representatives of the FirstHand program travelled to Washington, D.C. Tuesday, October 10th, ... mission is to change the trajectory of STEM education in America by dramatically ...
Breaking Biology Technology:
Cached News: