HOME >> BIOLOGY >> NEWS
JCI Table of Contents, January 15 2004

Inhibition of Borrelia burgdorferi protein prevents invasion of tick salivary glands and may reduce Lyme disease transmission

In the January 15 issue of the Journal of Clinical Investigation researchers from Yale University demonstrate that an outer surface protein, OspC, of the organism Borrelia burgdorferi, which causes Lyme disease, is critical for the organism's ability to invade the tick salivary gland and therefore be transmitted from ticks to humans.

Lyme disease was first named in 1977, when arthritis was observed in a cluster of children in Lyme, Connecticut. The bacterium Borrelia burgdorferi is transmitted to humans by the bite of infected deer ticks and in 2002 caused more than 23,000 infections in the United States, mostly localized to California and states in the northeastern, mid-atlantic, and upper north-central regions. Symptoms include a characteristic "bulls-eye" rash at the bite site, fever, malaise, and muscle and joint aches.

When a tick harboring the bacterium engorges, initiating transmission to a new host, B. burgdorferi decreases the expression of the outer surface protein OspA that allows the bacterium to adhere to the tick gut and instead begins expressing an alternative outer surface protein, OspC. In order to determine the function of OspC, Erol Fikrig and colleagues generated a strain of the B. burgdorferi bacterium that was deficient in OspC. These bacteria were able to survive and multiply in feeding ticks; however, they were unable to invade tick salivary glands. The results agreed with their findings that OspC binds to tick salivary gland extracts and that antibody inhibition of OspC inhibits the ability of B. burgdorferi to invade tick salivary glands, and therefore inhibits transmission to a new mammalian host. These insights into pathogen transmission might offer new approaches to reducing the incidence of Lyme disease.

TITLE: OspC facilitates Borrelia burgdorferi invasion of Ixodes scapul
'"/>

Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
15-Jan-2004


Page: 1 2 3 4 5 6 7 8 9 10 11 12

Related biology news :

1. JCI Table of Contents, 15 July 2004
2. JCI Table of Contents, November 3, 2003
3. JCI Table of Contents, 1 October, 2003
4. JCI Table of Contents, September 15, 2003
5. JCI Table of Contents
6. JCI Table of Contents, 15 August 2003
7. JCI Table of Contents, May 1, 2003
8. JCI Table of Contents, April 1, 2003
9. JCI Table of Contents, March 14, 2003
10. JCI Table of Contents, January 2, 2003
11. JCI Table of Contents, December 2, 2002

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/25/2018)... , ... December 24, 2018 , ... ... The Rockefeller University have discovered a new use for a long-standing computational concept ... spam control, blocking unwanted files and messages. Using blacklisting as a filter to ...
(Date:12/19/2018)... ... ... NDA Partners Chairman Carl Peck, MD, announced today that Deb Koeneman, ... and Radiological Health (CDRH), has been appointed a Partner in the firm. Ms. Koeneman ... more than 25 years of regulatory experience. In addition to her FDA career, she ...
(Date:12/18/2018)... ... December 18, 2018 , ... The nation’s ... into client marketing. The technology has been effective at reducing patient acquisition costs ... been working with clients nationwide on patient acquisition marketing programs. Traditional marketing for ...
Breaking Biology News(10 mins):
(Date:1/7/2019)... ... January 07, 2019 , ... Kainos Medicine Inc. today announced ... candidate, code-named "KM-819." KM-819 is an orally active small molecule that is ... Korea. , This Phase 1 randomized, double-blind, placebo-controlled dose-escalation study was to ...
(Date:12/20/2018)... ... December 20, 2018 , ... New Year’s brings reflection and ... in regulations in the European Union (EU) on the horizon, Jim Kasic, president and ... “The transition to the EU Medical Device Regulation (MDR), digital health, and big data ...
(Date:12/18/2018)... ... ... Patients with early stages of breast cancer who undergo partial breast proton ... irradiation, a new study suggests. , Patients with early stage breast cancer — stage ... the cancerous tumor because there is a 30 to 40 percent change the disease ...
(Date:12/13/2018)... ... December 13, 2018 , ... Microbial Discovery Group ... This has been part of their strategic plan and an important milestone in ... custom fermentation opportunities for MDG within the $44 Billion human probiotic market. This ...
Breaking Biology Technology:
Cached News: