View the PDF of this article at: https://www.the-jci.org/press/11548.pdf
Regulatory T cells help suppress graft rejection
CD4+CD25+ regulatory T cells (Treg cells) play a key role in regulating the immune response to both self- and foreign antigens by the suppression of aggressive T cell immune responses. As a result, they are critical in suppressing graft rejection. However it is not known whether this response is mediated by T cells that have been previously exposed to antigens (memory T cells) or by nave T cells. In the January 15 issue of the Journal of Clinical Investigation, Zhenhua Dai and colleagues from Yale University demonstrate that this suppression of graft rejection is donor-specific and is mediated by antigen-induced, but not nave Treg cells. The mechanism of this suppression is the apoptosis of memory T cells, which is dependent on the CD30 costimulatory molecule on Treg cells.
TITLE: CD4+CD25+ regulatory T cells suppress allograft rejection mediated by memory CD8+ T cells via a CD30-dependent mechanism
Yale University School of Medicine, New Haven, Connecticut, USA.
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View the PDF of this article at: https://www.the-jci.org/press/19727.pdf
Distinct roles for VEGF isoforms in bone development
During bone formation, epiphyseal cartilage is avascular until secondary ossification occurs. Vascularization of this maturing tissue relies on angiogenic recruitment from surrounding vessels. The growth factor VEGF has previously been shown to be critical for metaphyseal bone vascularization and is now implicated as an a
Contact: Brooke Grindlinger
Journal of Clinical Investigation