HOME >> BIOLOGY >> NEWS
JCI Table of Contents, March 14, 2003

cell markers in the peripheral blood, Catherine Verfaillie and colleagues tested peripheral blood from patients during acute crisis and chronic stages of disease for the presence of primitive hematopoietic progenitors (pages 811819). They found that during acute crisis, patients spontaneously mobilize significant numbers of progenitors with multiple-lineage and repopulation potential into the peripheral blood, suggesting that collection of these progenitors could yield a source of autologous cells suitable for genetic manipulation and subsequent transplantation.

CONTACT:
Catherine M. Verfaillie
University of Minnesota
MMC 716
420 Delaware Street SE
Minneapolis, MN 55455
USA
Phone 1-612-624-3921
Fax 1: 612-624-2436
E-mail: verfa001@tc.umn.edu

View the PDF of this article at: https://www.the-jci.org/press/15956.pdf

Mismatch repair awry in lung cancer

Mutations in DNA mismatch repair genes cause inherited colon cancer syndromes, and somatic mutations and promoter methylation of these genes have been found in a variety of human cancers characterized by microsatellite instability (MSI). Having previously shown that MSI and loss of hMLH1 protein expression is common in lung cancer patients from Taiwan, Yi-Ching Wang and colleagues now report (pages 887895) results from a comprehensive genetic and epigenetic analysis of 77 resected primary non-small cell lung tumors. Of these tumors, 70% had lost expression of either hMLH1 or hMSH2, and promoter methylation seemed to be the predominant cause. Moreover, promoter methylation of hMLH1 (whose expression is lost in over 50% of the samples) appears to be an early event in tumorigenesis and can be detected in sputum samples. Thus it might serve as a potential diagnostic marker.

<
'"/>

Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
14-Mar-2003


Page: 1 2 3 4 5 6 7

Related biology news :

1. JCI Table of Contents, 15 July 2004
2. JCI Table of Contents, January 15 2004
3. JCI Table of Contents, November 3, 2003
4. JCI Table of Contents, 1 October, 2003
5. JCI Table of Contents, September 15, 2003
6. JCI Table of Contents
7. JCI Table of Contents, 15 August 2003
8. JCI Table of Contents, May 1, 2003
9. JCI Table of Contents, April 1, 2003
10. JCI Table of Contents, January 2, 2003
11. JCI Table of Contents, December 2, 2002

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/3/2016)... -- Vigilant Solutions announces today that the ... solved two recent hit-and-run cases with the ... Solutions. Brian Wenberg explains, "I was ... out of a convenience store and witnessed an elderly male back out ... his vehicle and leaving the scene.  In his statement ...
(Date:2/2/2016)... , Feb. 2, 2016 Checkpoint ... that Rising Market Are you interested in ... forecasts revenues for checkpoint inhibitors. Visiongain,s report gives ... submarket, product and national level. Avoid falling ... what progress, opportunities and revenues those emerging cancer ...
(Date:2/1/2016)... -- Rising sales of consumer electronics coupled ... gesture control market size through ... electronics coupled with new technological advancements to drive global ... through 2020   --> Rising ... to drive global touchfree intuitive gesture control market ...
Breaking Biology News(10 mins):
(Date:2/9/2016)... , Feb. 9, 2016 This market ... the current and future prospects of the market in ... report include companies engaged in the manufacture of microbiology ... executive summary with a market snapshot providing the overall ... of this report. This section also provides the overall ...
(Date:2/9/2016)... , February 9, 2016 Three-Year ... Enables Children to Take Part in Life-Changing Camp ... new initiative designed to positively affect the lives of children born ... care. --> SHPG ) is announcing a new initiative ... diseases, as well as the future of rare disease care. ...
(Date:2/9/2016)... LONDON , Feb. 9, 2016 /PRNewswire/ ... (PTP1B) Inhibitors-Pipeline Insights, 2016", report provides in ... their development activities around the Protein-Tyrosine Phosphatase ... the product profiles in various stages of ... Phase II, Phase III and Preregistration. Report ...
(Date:2/8/2016)... 2016 Should antibiotic bone cement products be ... prevent infection after standard total hip or knee replacement ... Institute have been fielding a lot lately. ... Line?" --> "Antibiotic Bone Cement: ... --> While there isn,t a simple answer, ...
Breaking Biology Technology:
Cached News: