The association of hypertension with elastin haploinsufficiency strongly suggests that genes encoding vessel wall proteins, particularly elastin, should be considered as causal genes for hypertension.
In an accompanying commentary in the same issue of the Journal of Clinical Investigation, Jeanine D'Armiento, from Columbia University College of Physicians and Surgeons in New York discusses possible mechanisms by which a change in elastin content leads to alterations in cell signaling and subsequent changes in vessel wall structure.
TITLE: Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency
AUTHOR CONTACT:
Robert P. Mecham
Washington University School of Medicine, St. Louis, Missouri, USA.
Phone: 314-362-2254
Fax: 314-362-2252
E-mail: bmecham@cellbiology.wustl.edu
View the PDF of this article at: https://www.the-jci.org/press/19028.pdf
ACCOMANYING COMMENTARY: Decreased elastin in vessel walls puts the pressure on
AUTHOR CONTACT:
Jeanine D'Armiento
Columbia University College of Physicians and Surgeons, New York, New York, USA.
Phone: 212-305-3745
Fax: 212-305-5052
Email: jmd12@columbia.edu
View the PDF of this commentary at: https://www.the-jci.org/press/20226.pdf
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High rates of mitochondrial DNA mutations found in human colonic crypt stem cells
High rates of mitochondrial DNA (mtDNA) mutation occur in human colonic crypt stem cells. This findi
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Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
3-Nov-2003