TITLE: Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy

AUTHOR CONTACT:
Junichi Sadoshima
University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA.
Phone: 973-972-8619
Fax: 973-972-8919
E-mail: Sadoshju@umdnj.edu

View the PDF of this article at: https://www.the-jci.org/press/17700.pdf

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Diversity is the spice of autoimmune life

In the November 3 issue of the Journal of Clinical Investigation, Terri Laufer and colleagues from the University of Pennsylvania report that a diverse CD4+ T cell repertoire is required to activate autoreactive B cells to attack host tissues in autoimmune diseases such as systemic lupus erythematosus.

Whether help for autoantibody production comes from a finite number of T cells or a more diverse repertoire has remained, until now, an unanswered question. Laufer and colleagues used a chronic graft-versus-host disease model of systemic autoimmunity to examine the diversity of the T cell repertoire required for antinuclear antibody formation. The authors found that loss of B cell tolerance can be divided into two distinct components with different CD4+ cell requirements. CD4+ cell diversity is specifically required for the trafficking of CD4+ cells into the B cell follicle and the production of isotype-switched IgG autoantibodies. This work provides new insight into the pathogenesis of lupus and suggests therapeutic targets.

TITLE: Activation of diverse repertoires of autoreactive T cells enhances the loss of anti-dsDNA B cell tolerance

AUTHOR CONTACT:
Terri M. Laufer
University of Pennsylvania, Philadelphia, Pennsylvania, USA.'"/>

Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
3-Nov-2003