HOME >> BIOLOGY >> NEWS
JCI Table of Contents, November 3, 2003

R> Phone: 215-573-2955
Fax: 215-573-7599
E-mail: tlaufer@mail.med.upenn.edu

View the PDF of this article at: https://www.the-jci.org/press/18310.pdf

**********************************************

ARNT mice controlling skin function?

Junji Takeda and colleagues from Osaka University and the National Cancer Institute reveal that the aryl hydrocarbon receptor nuclear translocator (ARNT) affects the structure of ceramides in the skin and disrupts the function of the epidermal barrier, which protects against foreign environmental stimuli and injury. These findings are reported in the November 3 issue of the Journal of Clinical Investigation.

ARNT, a transcription factor of the Per/AHR/ARNT/Sim family, regulates gene expression in response to environmental stimuli such as xenobiotics and hypoxia. To examine its role in the epidermis, Takeda and colleagues disrupted Arnt in keratinocytes. While the architecture of the stratum corneum in Arnt/ mice was found to be similar to that in control mice, the permeability barrier function and the composition of ceramides were significantly different. In particular, 4-desaturated and 4-hydroxylated ceramide species were diminished in the Arnt/ mice, whereas 4-saturated ceramides were elevated.

These data suggest that ARNT regulates ceramide biosynthesis through 4-desaturation and that maintenance of ceramide composition is important in epithelial barrier function.

TITLE: Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function

AUTHOR CONTACT:
Junji Takeda
Osaka University Graduate School of Medicine, Osaka, Japan.
Phone: 81-6-6879-3262
Fax: 81-6-6879-3266
E-mail: takeda@mr-en
'"/>


Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
3-Nov-2003


Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15

Related biology news :

1. JCI Table of Contents, 15 July 2004
2. JCI Table of Contents, January 15 2004
3. JCI Table of Contents, 1 October, 2003
4. JCI Table of Contents, September 15, 2003
5. JCI Table of Contents
6. JCI Table of Contents, 15 August 2003
7. JCI Table of Contents, May 1, 2003
8. JCI Table of Contents, April 1, 2003
9. JCI Table of Contents, March 14, 2003
10. JCI Table of Contents, January 2, 2003
11. JCI Table of Contents, December 2, 2002

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/24/2016)... May 24, 2016 Ampronix facilitates superior patient care by providing unparalleled technology ... LCD display is the latest premium product recently added to the range of products ... ... ... 3d Imaging- LCD Medical Display- Ampronix News ...
(Date:5/3/2016)... , May 3, 2016  Neurotechnology, a provider ... MegaMatcher Automated Biometric Identification System (ABIS) , ... multi-biometric projects. MegaMatcher ABIS can process multiple complex ... any combination of fingerprint, face or iris biometrics. ... SDK and MegaMatcher Accelerator , which ...
(Date:4/19/2016)... DUBAI , UAE, April 20, 2016 ... can be implemented as a compact web-based "all-in-one" system ... in the biometric fingerprint reader or the door interface ... requirements of modern access control systems. The minimal dimensions ... the ID readers into the building installations offer considerable ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 2016  The Biodesign Challenge (BDC), a university competition ... harness living systems and biotechnology, announced its winning teams ... New York City . The ... projects at MoMA,s Celeste Bartos Theater during the daylong ... senior curator of architecture and design, and Suzanne ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case ... Denmark detail how a patient who developed lymphedema after being treated for breast cancer ... could change the paradigm for dealing with this debilitating, frequent side effect of cancer ...
(Date:6/23/2016)... -- On Wednesday, June 22, 2016, the NASDAQ ... Dow Jones Industrial Average edged 0.27% lower to finish at ... Stock-Callers.com has initiated coverage on the following equities: Infinity Pharmaceuticals ... NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ARLZ ... Learn more about these stocks by accessing their free trade ...
(Date:6/23/2016)... June 22, 2016  Amgen (NASDAQ: AMGN ... QB3@953 life sciences incubator to accelerate the ... shared laboratory space at QB3@953 was created to help ... obstacle for many early stage organizations - access to ... sponsorship, Amgen launched two "Amgen Golden Ticket" awards, providing ...
Breaking Biology Technology:
Cached News: