In an accompanying commentary, Yasuo Hamamori and Michael Schneider from Baylor College of Medicine in Houston, Texas, further discuss the roles of HDACs and Hop in cardiac hypertrophy.
TITLE: Cardiac hypertrophy and histone deacetylasedependent transcriptional repression mediated by the atypical homeodomain protein Hop
Jonathan A. Epstein
University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Phone: (215) 898-8731
Fax: (215) 573-2094
View the PDF of this article at: https://www.the-jci.org/press/19137.pdf
ACCOMPANYING COMMENTARY HATs off to HOP: recruitment of a class I histone deacetylase incriminates a novel transcriptional pathway that opposes cardiac hypertrophy
Michael D. Schneider
Center for Cardiovascular Development, Baylor College of Medicine, Houston, Texas, USA.
Phone: (713) 798-6683
Fax: (713) 798-7437
View the PDF of this commentary at: https://www.the-jci.org/press/19834.pdf
Activation of adenosine receptors protects the kidney
Mark Okusa and colleagues from the University of Virginia have investigated the contribution of A2A adenosine receptors expressed on bone marrow-derived cells to the protection of renal tissue against ischemia-reperfusion injury (IRI). The authors determined that activation of these receptors expressed on bone marrow-derived cells is necessary for tissue protection in a mouse model of IRI.
TITLE: Renal protection from ischemia mediated by A2A adenosine receptors on bone marrowderive
Contact: Brooke Grindlinger
Journal of Clinical Investigation