Following the recent FDA approval of recombinant BMP2 for specific uses, there remains great clinical interest in the role of BMPs and noggin in the regulation of bone formation and repair in a variety of conditions, including osteoporosis. Abe and colleagues suggest that recombinant BMP may prove useful in reversing age-related bone loss.
TITLE: Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice
Mount Sinai School of Medicine, New York, New York, USA.
Phone: (212) 241-8735
Fax: (212) 534-4820
View the PDF of this article at: https://www.the-jci.org/press/15543.pdf
Tracking autoimmune T cells in diabetes
Insulin-dependent diabetes mellitus is usually caused by autoimmune destruction of pancreatic beta cells by T cells. Methodologies to track the development, migration, and functional activation of one class of such T cells (CD4 T cells) have been limited. This is an important issue for studies designed to monitor the efficacy of potential intervention protocols. Luc Teyton and colleagues at The Scripps Research Institute in California, introduce an exciting new tetramer technology that allows a particular set of diabetogenic CD4 T cells to be quantified and tracked.
In an accompanying commentary, Edward Leiter from The Jackson Laboratory in Bar Harbor, Maine, discusses the potential uses of this technology that may help researchers design appropriate interventi
Contact: Brooke Grindlinger
Journal of Clinical Investigation