TITLE: Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity

AUTHOR CONTACT:
Luc Teyton
The Scripps Research Institute, La Jolla, California, USA.
Phone: (858) 784-2728
Fax: (858) 784-8166
E-mail: lteyton@scripps.edu

View the PDF of this article at: https://www.the-jci.org/press/18337.pdf

ACCOMPANYING COMMENTARY
Tracking autoimmune T cells in diabetes

AUTHOR CONTACT:
Edward H. Leiter

Jackson Laboratory, Bar Harbor, Maine, USA.
Phone: (207) 288-6370
Fax: (207) 288-6079
E-mail: ehl@jax.org

View the PDF of this commentary at: https://www.the-jci.org/press/19842.pdf

Antioxidants play a crucial role in estrogen-deficiency bone loss

Osteoporosis is an enormous clinical problem, yet the mechanisms through which estrogen-deficiency causes bone hyper-resorption remain controversial. A report by Timothy Chambers and colleagues at St. George's Hospital Medical School, London, may resolve these controversies by demonstrating that estrogen-deficiency sensitizes cells to oxidant signaling and stress by lowering thiol antioxidants in bone resorbing cells. This mechanism provides novel opportunities for the development of potential osteoporosis therapies.

TITLE: A crucial role for thiol antioxidants in estrogen-deficiency bone loss

AUTHOR CONTACT:
Timothy J. Chambers
St. George's Hospital Medical School, London, United Kingdom
Phone: 44-20-8725-5270
Fax: 44-20-8725-0064
E-mail: t.chambers@sghms.ac.uk

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Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
15-Sep-2003