TITLE: Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity
The Scripps Research Institute, La Jolla, California, USA.
Phone: (858) 784-2728
Fax: (858) 784-8166
View the PDF of this article at: https://www.the-jci.org/press/18337.pdf
Tracking autoimmune T cells in diabetes
Edward H. Leiter
Jackson Laboratory, Bar Harbor, Maine, USA.
Phone: (207) 288-6370
Fax: (207) 288-6079
View the PDF of this commentary at: https://www.the-jci.org/press/19842.pdf
Antioxidants play a crucial role in estrogen-deficiency bone loss
Osteoporosis is an enormous clinical problem, yet the mechanisms through which estrogen-deficiency causes bone hyper-resorption remain controversial. A report by Timothy Chambers and colleagues at St. George's Hospital Medical School, London, may resolve these controversies by demonstrating that estrogen-deficiency sensitizes cells to oxidant signaling and stress by lowering thiol antioxidants in bone resorbing cells. This mechanism provides novel opportunities for the development of potential osteoporosis therapies.
TITLE: A crucial role for thiol antioxidants in estrogen-deficiency bone loss
Timothy J. Chambers
St. George's Hospital Medical School, London, United Kingdom