AUTHOR CONTACT:
Matti Airaksinen
Institute of Biotechnology, University of Helsinki, Helsinki, Finland
Phone: 3589-191-59397
Fax: 3589-191-59560
E-mail: mairaksi@operoni.helsinki.fi
View the PDF of this article at: https://www.the-jci.org/press/17995.pdf
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Troponin T controls energetic affairs of the heart
It has long been noted that while patients with familial hypertrophic cardiomyopathy due to cardiac troponin T (cTnT) mutations often suffer sudden cardiac death, they do not develop significant ventricular hypertrophy (ventricle enlargement), suggesting that a distinct cellular mechanism apart from alterations in myocardial contractility is responsible. A new study by Jil Tardiff and colleagues at the Albert Einstein College of Medicine in New York has revealed that a single missense mutation in cTnT causes a striking disruption to energy metabolism, and cardiomyopathy.
In an accompanying commentary, Ketty Schwartz and Jean-Jacques Mercadier from INSERM in Paris discuss how troponin T regulates cardiac contraction and the functional consequences of this mutation.
TITLE: Decreased energetics in murine hearts bearing the R92Q mutation in cardiac troponin T
AUTHOR CONTACT:
Jil C. Tardiff
Albert Einstein College of Medicine, Bronx, New York, USA
Phone: 718-430-8914
Fax: 718-430-8989
E-mail: tardiff@aecom.yu.edu
View the PDF of this article at: https://www.the-jci.org/press/15967.pdf
ACCOMPANYING COMMENTARY:
Cardiac troponin T and familial hypertrophic cardiomyopathy: an energetic affair
AUTHOR CONTACT:
Ketty Schwartz
INSE
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Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
2-Sep-2003