HOME >> BIOLOGY >> NEWS
JCI table of contents, 1 July 2004

fectively inhibiting PAF function. To simulate menopause, these mice had their ovaries removed. The researchers found that in mice without the PAF receptor, ovarectomized mice had greatly improved bone mineral density as well as bone volume compared to ovarectomized mice that still had PAF gene function. Further molecular studies in these mice showed that osteoclasts (the bone cells that responsible for the breakdown of bone material) are responsible for PAF's mechanism of action. In addition, when mice were treated with a molecule that inhibits PAF receptor function, bone resorption was also reduced. These data indicate that inhibition of PAF activity presents a possible strategy for treating osteoporosis and other bone resoprtion diseases.

TITLE: Absence of platelet-activating factor receptor protects mice from osteoporosis following ovariectomy
AUTHOR CONTACT:
Satoshi Ishii
The University of Tokyo, Bunkyo, Tokyo, Japan.
Phone: 81-3-5802-2925; Fax: 81-3-3813-8732; Email: mame@m.u-tokyo.ac.jp

View the PDF of this article at: https://www.the-jci.org/press/20504.pdf


Immunology Link May Make You Lose Your Appetite

A decrease in food ingestion and anorexia are common symptoms during injury, illness, or inflammation. A key to the link between food intake and illness may be a recently identified molecule called ghrelin, which has previously been shown to play a part in maintaining metabolic energy balance. Now Dennis Taub and colleagues from the National Institute on Aging, have added to the ghrelin's role in the body, and show it also has activity in the immune system. They found that ghrelin receptors are expressed in cells in the immune system, and upon exposure to ghrelin, there was an inhibition of the production of molecules involved in the body's inflammatory response. The results here may furt
'"/>

Contact: Laurie Goodman
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
1-Jul-2004


Page: 1 2 3 4 5 6 7 8 9 10 11

Related biology news :

1. Chemical engineering grad students will take notable national awards
2. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
3. JCI table of contents September 15, 2004
4. JCI table of contents: 1 September, 2004
5. Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
6. JCI table of contents, 16 August, 2004
7. JCI table of contents, 2 August, 2004
8. When male fish hum, females swim in, thanks to hormones, adaptable hearing
9. Search and destroy protein turns tables on HIV
10. JCI table of contents, 15 June 2004
11. JCI table of contents, 1 June 2004

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: JCI table contents July

(Date:4/16/2014)... Florida State University researchers have identified a new syndrome ... density and muscle mass with obesity. , "It used ... the better your bones would be because the bones ... Stiebeling Professor of Nutrition at Florida State. "But, that,s ...
(Date:4/16/2014)... Doucet of the Centre INRSInstitut Armand-Frappier has just received a ... the amount of nearly US$600,000. The 5-year grant is to ... RNases and to explore their biomedical potential in the field ... , "Receiving a grant at this level is an ...
(Date:4/16/2014)... The "brush border" a densely packed array of ... the cells that line our intestines., Vanderbilt University researchers ... structure, which is critical for absorbing nutrients and defending ... journal Cell , reveal a role for adhesion ...
Breaking Biology News(10 mins):Researchers: Obesity can amplify bone and muscle loss 2High-level NIH grant goes to professor Nicolas Doucet of INRS 2Vanderbilt researchers discover how intestinal cells build nutrient-absorbing surface 2Vanderbilt researchers discover how intestinal cells build nutrient-absorbing surface 3
(Date:1/15/2014)... 2014 The Microcompetition with Foreign DNA ... disease. One of these latent viruses is the Epstein ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... by the theory, a study found that RA patients ... (1). , What is Microcompetition? , Dr. Hanan ...
(Date:1/15/2014)... Sunnyvale, CA (PRWEB) January 15, 2014 ... of high throughput research solutions, today announced that ... companies, has received delivery of Freeslate’s CM ... form screening. , Lupin, headquartered in Mumbai, ... quality, affordable generic and branded formulations and Active ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Date: Friday, ... p.m. , Location: Warrington Country Club, 1360 Almshouse Road, ... Foundation, the only national nonprofit organization solely dedicated to ... quality of life for those affected worldwide, will host ... Warrington Country Club in Warrington, Pa. , Each ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider ... major scientific, regulatory, business, and media events in ... , today announced its former associate Virginia Cox , ... office. Virginia Cox re-joins ... Commissioner for the Office of External Affairs at the U.S. ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2
Cached News: