HOME >> BIOLOGY >> NEWS
JCI table of contents, 1 June 2004

Atherosclerosis Treatment Needs to Go with the Flow

Branch points in the arteries are a common area of atherosclerotic disease, resulting in the occlusion of both branches. These branch points can generally be defined as a main branch and a side branch, and, in treating the disease, the question of what is the optimal course of action, opening the main branch, the side branch, or both, remains uncertain. Studies have shown that using a stent to open a blocked blood vessel is generally more successful that balloon angioplasty, when one is treating a lesion in non-bifurcated area. Current data, however, indicate no such superiority in the use of stents to treat lesions in branching passages. Yoram Richter and colleagues, from HarvardM.I.T. Division of Health Sciences and Technology, provide a hemodynamic analysis (an analysis of the forces of blood flow) in the region of the bifurcated vasculature to show that stenting of both passages results in a blood flow pattern that is inherently harmful to the main branch, and results in rapid re-occlusion of the main branch. To investigate this system, the authors developed a new dynamic bench top fluid mechanical model system. This system provides a major advance over previous static models by allowing not only the prediction of areas in the blood vessels likely to be damaged, but also by reflecting the true active nature of the arterial system that compensates for and minimizes any disturbance. The authors further tested their in vitro predictions in an animal model, and, in seeing in the animals what was predicted to occur from their bench top model, established the strength of their in vitro modeling system. This study provides an explanation for why stenting in forked blood vessel regions has had a low success rate, and also provides a direction for appropriate treatment of these commonly blocked regions.

An accompanying commentary from R. Wayne Alexander at Emory University, provides a detaile
'"/>

Contact: Laurie Goodman
press_releases@the-jci.org
212-342-4259
Journal of Clinical Investigation
1-Jun-2004


Page: 1 2 3 4 5 6 7 8 9 10 11

Related biology news :

1. Chemical engineering grad students will take notable national awards
2. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
3. JCI table of contents September 15, 2004
4. JCI table of contents: 1 September, 2004
5. Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
6. JCI table of contents, 16 August, 2004
7. JCI table of contents, 2 August, 2004
8. When male fish hum, females swim in, thanks to hormones, adaptable hearing
9. JCI table of contents, 1 July 2004
10. Search and destroy protein turns tables on HIV
11. JCI table of contents, 15 June 2004

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2017)... and ITHACA, N.Y. , June ... Cornell University, a leader in dairy research, today announced ... designed to help reduce the chances that the global ... onset of this dairy project, Cornell University has become ... Sequencing the Food Supply Chain, a food safety initiative ...
(Date:5/23/2017)... May 23, 2017  Hunova, the first robotic gym for the rehabilitation ... officially launched in Genoa, Italy . The first 30 ... and the USA . The technology was developed and ... by the IIT spin-off Movendo Technology thanks to a 10 million euro ... Release, please click: ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... (PRWEB) , ... October 11, 2017 , ... ... any gene in its endogenous context, enabling overexpression experiments and avoiding the use ... with small RNA guides is transformative for performing systematic gain-of-function studies. , ...
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... Angeles, CA (PRWEB) , ... ... ... Inc., a development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, ... uses of targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in ...
(Date:10/10/2017)... SANTA BARBARA, CALIFORNIA (PRWEB) , ... October 10, ... ... risk management, technological innovation and business process optimization firm for the life sciences ... the BoxWorks conference in San Francisco. , The presentation, “Automating GxP ...
Breaking Biology Technology:
Cached News: