HOME >> BIOLOGY >> NEWS
JCI table of contents, 15 March 2004

Profiling Prostate Cancer

Determining proper treatment for individuals diagnosed with prostate cancer suffers because of the current unreliability of methods to predict the clinical course of the disease. Existing procedures for patient stratification include a series of clinical, biochemical, and histopathological examinations, such as prostate specific antigen (PSA) levels, tumor stage, Gleason score, and genetic approaches that look for specific oncogenic alterations. Used together, these tools still have only limited classification capability. Recent studies utilizing cDNA microarray technology have indicated that specific genetic markers may be useful as potential prostate cancer markers. In the March 15 issue of the Journal of Clinical Investigation, Gennadi Glinsky and colleagues, from the Sydney Kimmel Cancer Center, San Diego, CA, present a highly accurate gene-expression-based prostate cancer recurrence predictor algorithm. The authors used a microarray-based gene-expression profiling method to determine molecular signatures that could distinguish subgroups of patients with different disease outcomes. The algorithm was developed utilizing an analysis that assessed expression profiles of over 12,000 genes from 100 different tumors. Five highly discriminating gene-expression clusters were assigned from this analysis and then tested on a new set of 79 patients. Of those patients who ultimately had recurrence of prostate cancer, the algorithm correctly classified 88% of these patients into the poor-prognosis group. This study provides a significant advance in our ability to properly classify the clinical outcome of prostate cancer patients for use in determining appropriate treatment.

In an accompanying commentary, Mitchell Benson and James McKiernan of Columbia University, place this study in context with other methods for predicting clinical outcome, and how combination of these methods with that presented here should enhance
'"/>

Contact: Laurie Goodman
lgoodman@the-jci.org
212-342-4159
Journal of Clinical Investigation
15-Mar-2004


Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14

Related biology news :

1. Chemical engineering grad students will take notable national awards
2. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
3. JCI table of contents September 15, 2004
4. JCI table of contents: 1 September, 2004
5. Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
6. JCI table of contents, 16 August, 2004
7. JCI table of contents, 2 August, 2004
8. When male fish hum, females swim in, thanks to hormones, adaptable hearing
9. JCI table of contents, 1 July 2004
10. Search and destroy protein turns tables on HIV
11. JCI table of contents, 15 June 2004

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/19/2019)... , ... November 19, 2019 , ... Hosted at the ... , MJBizCon 2019 is the largest gathering of MJBiz business professionals in ... and programming to benefit every sector, there is no show quite like it. Atlantic ...
(Date:11/14/2019)... ... ... Personalized Stem Cells, Inc (“PSC”), a human adipose-derived stem cell ... for stem cell treatment of knee osteoarthritis . The first treatment came shortly after ... Biopharma. , In July of 2019, PSC received FDA approval for a ...
(Date:11/12/2019)... ... November 12, 2019 , ... ... leader in the design and manufacturer of technical ergonomic seating solutions, announced ... footrests compliant with Healthier Hospital Initiative guidelines. Established by Practice Greenhealth, a ...
Breaking Biology News(10 mins):
(Date:11/22/2019)... ... ... Lajollacooks4u is preparing for another busy holiday season. Not only has ... popular cooking classes and team-building events, but the company has also booked numerous companies ... a favorite for companies of all sizes since 2008. Each event is completely ...
(Date:11/12/2019)... , ... November 12, 2019 , ... ... solutions for the food and beverage industry launched a new innovative website. , ... digital experience. Now, the website offers global visitors updated ingredient usage tables by ...
(Date:11/6/2019)... ... 2019 , ... LeadingBiotech ,?an exclusive event series bringing ... East/West CEO conference to be held January 11-12, 2020 at the ... week of the J.P. Morgan Healthcare Conference and other biotech industry conferences, collectively ...
(Date:11/2/2019)... ... October 31, 2019 , ... Join ... in a live webinar on Friday, November 15, 2019 at 1pm ... Immunosequencing, the science of profiling T-cell receptors (TCRs) and B-cell receptors (BCRs), has ...
Breaking Biology Technology:
Cached News: