HOME >> BIOLOGY >> NEWS
JCI table of contents, 15 October, 2003

FGF-2 to the rescue following traumatic brain injury

In the October 15 issue of the Journal of Clinical Investigation, Michael Moskowitz and colleagues from Harvard Medical School report that fibroblast growth factor-2 (FGF-2) plays a critical role in the ability of the brain to make new cells following traumatic brain injury (TBI). The authors also demonstrate that administration of FGF-2 boosts the production of new brain cells and protects existing neurons from degeneration following injury. The study suggests that FGF-2 supplementation may improve the outcome of individuals who suffer TBI following motor vehicle accidents or other brain injuries.

The brain can be distinguished from other organs and tissues of the body by its limited ability to repair itself. This lack of self-repair following TBI or disease can often result in severe deficits in cognitive, physical, and psychological skills.

However, in the last several decades, mounting evidence has led to the view of the brain as a dynamic, plastic organ, endowed with some potential for self-repair and regeneration. Recent progress in understanding continued neurogenesis the generation of new neurons (nerve cells) - in the adult brain has raised hopes that self-renewal leading to structural repair by new neurons may even be possible.

Moskowitz and fellow researchers examined the role of FGF-2 in the regulation of neurogenesis and neuron loss in a specific region of the brain known as the hippocampal dentate gyrus (DG), in an animal model of TBI. Mice lacking FGF-2, showed a decreased ability to protect existing neurons and generate new neurons following TBI, when compared to controls, indicating that FGF-2 plays a critical role in stabilizing cell loss following injury.

In an effort to limit cell loss and enhance cell proliferation in the DG following TBI, the authors administered FGF-2 by gene delivery and found that this method was indeed able to limit the
'"/>

Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
15-Oct-2003


Page: 1 2 3 4 5 6 7 8 9 10 11 12 13

Related biology news :

1. Chemical engineering grad students will take notable national awards
2. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
3. JCI table of contents September 15, 2004
4. JCI table of contents: 1 September, 2004
5. Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
6. JCI table of contents, 16 August, 2004
7. JCI table of contents, 2 August, 2004
8. When male fish hum, females swim in, thanks to hormones, adaptable hearing
9. JCI table of contents, 1 July 2004
10. Search and destroy protein turns tables on HIV
11. JCI table of contents, 15 June 2004

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/30/2019)... ... December 30, 2019 , ... It’s been quite a ... seen its highest sales in 2019, having hosted a multitude of team-building events and ... visited the company’s La Jolla-based venue, and the company has worked hard to accommodate ...
(Date:12/18/2019)... ... December 17, 2019 , ... PM360, a leading ... diagnostics industries, has named Pharmafusion LLC as one of the most innovative startups ... and its founder/CEO Jonathan Retano. Earlier in the year, Pharmafusion was featured as ...
(Date:12/4/2019)... , ... December 03, 2019 , ... ... today announced that Agenus , a clinical-stage immuno-oncology company developing therapies to ... antibody R&D workflow platform. Agenus will use the platform to support immunotherapy and ...
Breaking Biology News(10 mins):
(Date:12/27/2019)... ... December 27, 2019 , ... Vici Health Sciences is ... pipeline that offers patients and healthcare providers options in the treatment of ... collaboration with doctors and managed care professionals and developed at Vici’s R&D ...
(Date:12/18/2019)... ... 17, 2019 , ... Innovative Health, Inc. today ... devices since the company’s inception in 2016. This marks a record in the ... Johnson company) have received 2 and 4 EP device clearances, respectively, in the ...
(Date:12/18/2019)... ... December 18, 2019 , ... Tune in to CNBC on Saturday, December 28th ... local listings for more information on this program. , With a look at ... simplify complex system to increase the efficiency, safety and effectiveness of equipment, systems, and ...
(Date:12/6/2019)... ... December 06, 2019 , ... ... has received FDA 510(k) clearance for its latest CAPERE® Thrombectomy System for ... suggests the CAPERE® offers great benefits for first-in-line treatment for nonsurgical removal ...
Breaking Biology Technology:
Cached News: