JCI table of contents, 15 October, 2003

odium balance is believed to be a crucial mechanism that permits the excretion of water and electrolytes from the kidney into the urine to be finely balanced with dietary salt intake.

TITLE: Uroguanylin knockout mice have increased blood pressure and impaired natriuretic response to enteral NaCl load

John N. Lorenz
University of Cincinnati School of Medicine, Cincinnati, Ohio, USA.
Phone: (513) 558-3097
Fax: (513) 558-5738
Email: john.lorenz@uc.edu

View the PDF of this article at: https://www.the-jci.org/press/18743.pdf

A novel role for uroguanylin in the regulation of sodium balance

Leonard R. Forte
University of Missouri, Columbia, Missouri, USA.
Phone: (573) 814-6000
Fax: (573) 814-6551
E-mail: lrf@missouri.edu

View the PDF of this commentary at: https://www.the-jci.org/press/20057.pdf

Immunological tug of war between IL-12 and IL-23

Experimental autoimmune encephalomyelitis (EAE) is an animal model of human multiple sclerosis. Microglia and macrophages that reside within the central nervous system (CNS) are a source of the inflammatory cytokines IL-23 and IL-12. Until recently it was considered that IL-12 was a major mediator in the development of EAE, however within the last year it has been reported that IL-23 and not IL-12 is essential in the development of EAE. Burkhard Becher and colleagues from the University of Zurich, Switzerland, and Dartmouth College, New Hampshire, USA, now show that the p40 subunit, shared by both IL-12 and IL-23, plays a critical role in maintaining encephalitogenicity during the course of this disease. The authors d

Contact: Brooke Grindlinger
Journal of Clinical Investigation

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