HOME >> BIOLOGY >> NEWS
JCI table of contents, 15 October, 2003

emonstrated that in the absence of p40 expression within the CNS, EAE was delayed and less severe. This study suggests that cells resident in the CNS can control the degree of T cell encephalitogenicity and that therapeutic intervention by targeting the IL-12/23 pathway may provide a powerful inhibitor of multiple sclerosis disease progression without the side-effects of broad immune suppression.

TITLE: IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis

AUTHOR CONTACT:
Burkhard Becher
University Hospital of Zurich, Zurich, Switzerland.
Phone: +41-0-1-255-8842
Fax: +41-0-1-255-9765
Email: burkhard.becher@usz.ch

View the PDF of this article at: https://www.the-jci.org/press/19079.pdf


Long-lost ancestral liver cells are found

The liver is the central organ of nutrient digestion and metabolism. In adult life, it is a quiescent organ, except when subjected to injury, when it responds with neoproliferation of mature hepatocytes and other liver cells to the point of complete organ regeneration. There is also a contribution from resident hepatic stem cells, about which little is known. Miguel Marcos and colleagues from Universidad Autnoma de Madrid, Spain, now describe a population of embryonic ancestor cells, called progenitors, in the liver that selectively express liver-specific genes and proteins during development. These cells were evaluated for their growth potential, differentiation, and clonal growth in media supplemented with different growth factors. The authors demonstrated that purified progenitor cells cocultured with cell-depleted fetal liver fragments successfully engrafted and repopulated liver compartments, suggesting that they may be the embryonic stem cells respo
'"/>

Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
15-Oct-2003


Page: 1 2 3 4 5 6 7 8 9 10 11 12 13

Related biology news :

1. Chemical engineering grad students will take notable national awards
2. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
3. JCI table of contents September 15, 2004
4. JCI table of contents: 1 September, 2004
5. Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
6. JCI table of contents, 16 August, 2004
7. JCI table of contents, 2 August, 2004
8. When male fish hum, females swim in, thanks to hormones, adaptable hearing
9. JCI table of contents, 1 July 2004
10. Search and destroy protein turns tables on HIV
11. JCI table of contents, 15 June 2004

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/1/2020)... ... February 01, 2020 , ... Liver cancer, called hepatocellular carcinoma (HCC), ... die from the disease. HCC is the 5th most common cancer and the 2nd ... when it comes to incidence of HCC, while China has half of all patients ...
(Date:1/29/2020)... ... January 29, 2020 , ... Jason Burke has joined CREO, ... providing consulting services for strategy, research and development and data governance to healthcare ... Managing Partner of CREO, an innovative management consulting and advisory firm based in ...
(Date:1/29/2020)... (PRWEB) , ... January 29, 2020 , ... ... plasmid, announced it will start production of a DNA vaccine against the novel ... with Inovio Pharmaceuticals. A grant of up to $9 million from the Coalition ...
Breaking Biology News(10 mins):
(Date:2/19/2020)... ... February 18, 2020 , ... Intech , the ... a new and unified global brand identity, as it celebrates its 20th anniversary. ... as well as an enthusiasm for designing and manufacturing state-of-the-art medical devices, Intech ...
(Date:2/11/2020)... ... February 11, 2020 , ... ... announce the successful results from a long-term follow-up clinical study of outpatient ... fixation device (INSPAN LLC). Unlike extension block design, the Inspan device fixates ...
(Date:2/5/2020)... ... February 04, 2020 , ... ... characterizing microbiome populations down to the strain level, has announced a new distribution ... Biome’s microbiome kits and other products to companies and research organizations in China, ...
(Date:2/3/2020)... ... February 03, 2020 , ... Global molecular ... that OmniType, the 11-locus, single tube multiplex successor to Holotype HLA is available ... featuring locus-multiplexing and short library preparation, for HLA genotyping from sample to answer ...
Breaking Biology Technology:
Cached News: