JCI table of contents, 15 October, 2003

emonstrated that in the absence of p40 expression within the CNS, EAE was delayed and less severe. This study suggests that cells resident in the CNS can control the degree of T cell encephalitogenicity and that therapeutic intervention by targeting the IL-12/23 pathway may provide a powerful inhibitor of multiple sclerosis disease progression without the side-effects of broad immune suppression.

TITLE: IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis

Burkhard Becher
University Hospital of Zurich, Zurich, Switzerland.
Phone: +41-0-1-255-8842
Fax: +41-0-1-255-9765
Email: burkhard.becher@usz.ch

View the PDF of this article at: https://www.the-jci.org/press/19079.pdf

Long-lost ancestral liver cells are found

The liver is the central organ of nutrient digestion and metabolism. In adult life, it is a quiescent organ, except when subjected to injury, when it responds with neoproliferation of mature hepatocytes and other liver cells to the point of complete organ regeneration. There is also a contribution from resident hepatic stem cells, about which little is known. Miguel Marcos and colleagues from Universidad Autnoma de Madrid, Spain, now describe a population of embryonic ancestor cells, called progenitors, in the liver that selectively express liver-specific genes and proteins during development. These cells were evaluated for their growth potential, differentiation, and clonal growth in media supplemented with different growth factors. The authors demonstrated that purified progenitor cells cocultured with cell-depleted fetal liver fragments successfully engrafted and repopulated liver compartments, suggesting that they may be the embryonic stem cells respo

Contact: Brooke Grindlinger
Journal of Clinical Investigation

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