rface is also suggested to help PDGF-B localize in or near ECs. Betsholtz and colleagues found that without this motif pericyte recruitment was limited, and existing pericytes were partially detached from the vessel wall, which resulted in hemorrhaging. The report supports the notion that pericytes serve an important function in tumor vessels and highlights PDGF-B and PDGF-Rbeta as promising targets for therapeutic intervention in the treatment of tumors.

TITLE: Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

AUTHOR CONTACT:
Christer Betsholtz
Gteborg University, Gteborg, Sweden.
Phone: +46-31-7733460
Fax: +46-31-4161108
E-mail: Christer.Betsholtz@medkem.gu.se

View the PDF of this article at: https://www.the-jci.org/press/18549.pdf

ACCOMPANYING COMMENTARY:
What brings pericytes to tumor vessels?

AUTHOR CONTACT:
Rakesh K. Jain
Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Phone: (617) 726-4083
Fax: (617) 724-1819
E-mail: jain@steele.mgh.harvard.edu

View the PDF of this commentary at: https://www.the-jci.org/press/20087.pdf

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Researchers identify a small gene deletion associated with pseudohypoparathyroidism-Ib

Parathyroid hormone (PTH) is produced by the parathyroid gland and helps regulate calcium and phosphate levels in the blood. The condition, pseudohypoparathyroidism (PHP) is a genetic disorder where there is an adequate level of PTH however the body cannot respond to it. PHP type Ib (PHP-Ib) is characterized by resistance to PTH confined to the kidney, which caus
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Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
15-Oct-2003

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