HOME >> BIOLOGY >> NEWS
JCI table of contents, 16 August, 2004

t of the means to evade the MIC activated immune surveillance system may be a mechanism for prostate cancer progression, that soluble MIC measurement may be a useful biomarker for disease progression, and that cytokine treatment may aid in reestablishing natural killer cell anti-tumor activity.

TITLE: Prevalent expression of the immunostimulatory MHC class I chainrelated molecule is counteracted by shedding in prostate cancer

AUTHOR CONTACT:
Jennifer D. Wu University of Washington, 325 9th Ave., Seattle, WA 98104, USA
Phone: (206) 341-5349; Fax: (206) 341-5302. E-mail: wuj@u.washington.edu

View the PDF of this article at: https://www.the-jci.org/press/22206.pdf


Having an Affinity for Diabetes

Insulin autoantibodies (IAAs) are often the first antibodoies directed against self that are recognized in the natural history of childhood diabetes. Not all IAA-positive children, however, go on to develop additional autoantibodies against antigens from pancreas islet cells and, from there, progress to type 1 diabetes mellitus (T1DM). In a standard immune response, antibody maturation through repeated exposure to antigen results in increased antibody affinity. Ezio Bonifacio and colleagues, from the Diabetes Research Institute in Germany, analyzed IAA affinity in IAA-positive samples from children of the BABYDIAB cohort to examine the relationship of antibody affinity to development of T1DM. Using a competitive radiobinding assay, the authors found that the presence of high-affinity IAAs in a sample correlated with the individual having HLA DRB1*04 and subsequently developing multiple islet autoantibodies and T1DM. In examining epitope specificity, they further found that high- and low-affinity IAAs were reactive with different insulin epitopes and that high-affinity IAAs were reactive with (pro)insulin, whi
'"/>

Contact: Laurie Goodman
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
16-Aug-2004


Page: 1 2 3 4 5 6 7 8 9 10

Related biology news :

1. Chemical engineering grad students will take notable national awards
2. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
3. JCI table of contents September 15, 2004
4. JCI table of contents: 1 September, 2004
5. Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
6. JCI table of contents, 2 August, 2004
7. When male fish hum, females swim in, thanks to hormones, adaptable hearing
8. JCI table of contents, 1 July 2004
9. Search and destroy protein turns tables on HIV
10. JCI table of contents, 15 June 2004
11. JCI table of contents, 1 June 2004

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: JCI table contents August

(Date:11/10/2014)... appearing on U.S. store shelves in early 2010, and ... The small packets can be tossed into a washing ... or powder. The convenience, though, has come with risks ... at Nationwide Children,s Hospital found that from 2012 through ... children younger than 6 years of age swallowing, inhaling, ...
(Date:11/6/2014)... because of metastasis, yet progress in preventing and ... "It,s been particularly challenging to design drugs that ... in systems biology at Harvard Medical School. ... they,ve already metastasized." , Gujral and colleagues have ... researchers better understand how metastasis begins. Their findings ...
(Date:11/5/2014)... Rio de Janeiro, Brazil -Individuals show great diversity in ... importantly, males and females greatly differ in their perceptual ... kinds of smell tests. , Sex differences ... social behaviors and may be connected to one,s perception ... and emotions. Thus, women,s olfactory superiority has been suggested ...
Breaking Biology News(10 mins):Study finds laundry detergent pods, serious poisoning risk for children 2Migration negation 2Migration negation 3The female nose always knows: Do women have more olfactory neurons? 2
(Date:11/26/2014)... -- Theravalues Corporation est fier d,annoncer le lancement ... salon Hi Europe 2014 (du 2 au 4 décembre ... Curcumine la plus biodisponible actuellement sur le marché, ... ingrédients approuvés par les règlements européens. ... la racine de curcuma ( Curcuma longa ) ...
(Date:11/24/2014)... Five American winners will receive ... Awards for Medical Sciences", in its 8 th ... , on 15 December 2014.      ... Carter Center which won the Hamdan Award for Volunteers ... programs that aim to improve health and promote peace ...
(Date:11/24/2014)... USA (PRWEB) November 23, 2014 One of ... field of optics and photonics is now available to high ... very low cost. SPIE, the international society for optics ... to the complete SPIE Digital Library available to ... price. , “Light-based technologies are integral to all areas of ...
(Date:11/24/2014)... Senior Vice President, General Manager for Clinical ... acumen Elsevier , a world-leading provider ... congratulates Diane Bartoli , Senior Vice President and ... Solutions, for being recognized in the 13 th ... Profiles in Diversity Journal ® . ...
Breaking Biology Technology:La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 3Five US Winners Among Recipients of Hamdan Medical Awards 2SPIE Digital Library Now Available to High Schools, Two-Year Colleges at No or Low Cost 2Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 2Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 3
Cached News: