JCI table of contents, 1...( roving xenotransplantation the researc...)

roving xenotransplantation, the researchers performed cardiac grafts from the transgenic mice and promoted transplant rejection by immune system induction. Transgenic hearts were protected from rejection that is manifested as widespread intravascular thrombosis and platelet infiltration in small blood vessels of wild-type mice. Thus, CD39-transgenic cells may aid in improving xenotransplantation protocols as well as other clinical problems involving vascular injury and thrombosis.

TITLE: Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation

AUTHOR CONTACT:
Anthony J.F. d'Aspice
St. Vincent's Hospital- Melbourne, Fitzroy, Victoria, Australia.
Phone: 61-3-9288-3140; Fax: 61-3-9288-3151; E-mail: Anthony.DAPICE@svhm.org.au

View the PDF of this article at: https://www.the-jci.org/press/19560.pdf

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B7-1 Beyond the Immune System

Proteinuria is a hallmark of nephrotic disease and results from dysfunction in the podocyte structure of kidney glomeruli. While a great deal has been discovered in the last several years about the molecular underpinnings of proteinuria, Peter Mundel and colleagues, from Albert Einstein College of Medicine, have identified an unexpected player in the development of this disease: B7-1, a transmembrane protein primarily known for its role in the immune system. B7-1 is expressed on antigen-presenting cells, where it acts as a T cell costimulatory molecule. In this study, using an RNA differential display screen, the authors found increased expression of B7-1 in podocytes from a3-integrindeficient mice, which have abnormal podocyte structures. They further observed induction of podocyte B7-1 expression in other models of nephrotic syndrome and found a correlation b
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Contact: Laurie Goodman
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
17-May-2004

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