View the PDF of this article at: https://www.the-jci.org/press/20515.pdf

New Paths for Platelet Fragmentation in Thrombocytopenia

One of the complications of HIV infection is the development of immunologic thrombocytopenia. Peripheral destruction of platelets through antibody-induced platelet fragmentation is increased in this disease. Previous reports have indicated Ab-induced fragmentation was due to the generation of reactive oxygen species (ROS), including peroxide. An active NADPH oxidase pathway is required for ROS generation. Simon Karpatkin and colleagues of New York University School of Medicine now show that Ab-induced fragmentation also requires activation by the platelet 12-lypoxygenase (12-LO) pathway. The discovery of a role for the 12-LO pathway in thrombocytopenia provides a new area to explore for reversing or preventing this disease.

TITLE: Complement-independent Ab-induced peroxide lysis of platelets requires 12-lipoxygenase and a platelet NADPH oxidase pathway

AUTHOR CONTACT:
Simon Karpatkin
New York University School of Medicine, New York, New York, USA.
Phone: 212-263-5609
Fax: 212-263-0695
E-mail: simon.karpatkin@med.nyu.edu

View the PDF of this article at: https://www.the-jci.org/press/20726.pdf

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Contact: Laurie Goodman
lgoodman@the-jci.org
212-342-4159
Journal of Clinical Investigation
2-Apr-2004