h experimentally induced seizures in rats and in patients with temporal lobe epilepsy. In instances of experimentally-produced prolonged seizures that damaged the hippocampus in rats, Bim expression increased. Blocking upstream activators of Bim or using Bim antisense to block Bim expression reduced neuronal damage. Of interest, in the hippocampus of epileptic patients, Bim appeared to be selectively down-regulated. These results suggest a means by which the brain may protect itself from additional neural damage following epileptic seizures. Targeting this molecular pathway may be worthwhile for ameliorating seizure-induced brain injuries.
An accompanying commentary by Jerome Niquet and Claude Wasterlain, of Epilepsy Research Laboratory, place this work in context with the complexity of cell-death pathways and highlight specific areas of future analysis that are still required to understand the molecular mechanisms at play in neuronal damage.
TITLE: Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy
AUTHOR CONTACT:
David C. Henshall
Robert S. Dow Neurobiology Laboratories, Portland, Oregan, USA.
Phone: 503-413-5260
Fax: 503-413-5465
E-mail: dhenshall@downeurobiology.org
View the PDF of this article at: https://www.the-jci.org/press/19971.pdf
ACCOMPANYING COMMENTARY: Bim, Bad, and Bax: a deadly combination
in epileptic seizures
AUTHOR CONTACT:
Jerome Niquet
Epilepsy Research Laboratory, West Los Angeles, California, USA.
Phone: 310-478-3711 ext. 41974
Fax: 310-268-4856
E-mail: jniquet@ucla.edu
View the PDF of this commentary at: https://www.the-jci.org/press/21478.pdf
'"/>
Contact: Laurie Goodman
lgoodman@the-jci.org
212-342-4159
Journal of Clinical Investigation
2-Apr-2004
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 Related biology news :1.
Chemical engineering grad students will take notable national awards2.
New study indicates arsenic could be suitable as first-line treatment in type of leukaemia3.
JCI table of contents September 15, 20044.
JCI table of contents: 1 September, 20045.
Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth6.
JCI table of contents, 16 August, 20047.
JCI table of contents, 2 August, 20048.
When male fish hum, females swim in, thanks to hormones, adaptable hearing9.
JCI table of contents, 1 July 200410.
Search and destroy protein turns tables on HIV11.
JCI table of contents, 15 June 2004