JCI table of contents, 2 August, 2004

cell cycle might be involved in this mechanism as they are important for stimulating or inhibiting the growth of a variety of cell types, and likely affect the growth and repair of tissue damage. To test their hypothesis, they used mice that are defective in the production of a cell cycle molecule called p27kip1 and show that these mice, after experiencing mechanical damage to an artery, had increased lesion formation with increased infiltration by immune and inflammatory cells. When the researchers transplanted bone-marrow cells from p27kip1 defective mice into normal mice, these transplant mice had higher a higher prevalence of arterial blockage. To assess the importance of immune cells in the repair of vascular tissues, the authors looked at the vascular repair in mice that were transplanted with bone marrow from mice that are unable to make immune cells, these are called RAG deficient mice. Mice transplanted with normal bone marrow cells showed greatly exacerbated the vascular injury compared to mice transplanted with bone marrow cells from RAG deficient mice. The data here show a direct link vascular inflammation and proliferation, and indicate that treatment for cardiovascular disease should target factors involved in immunity and inflammation.

TITLE: Bone marrow-derived immune cells regulate vascular disease through a p27Kip1-dependent mechanism

Elizabeth G. Nabel National Heart, Lung, and Blood Institute, NIH, 50 Center Dr, Bethesda, MD 20892, USA
Phone: 301-496-1518; Fax: 301-402-7560; E-mail: nabele@nhlbi.nih.gov

View the PDF of this article at: https://www.the-jci.org/press/20176.pdf


Interferon Interference Obstructs Ducts

Biliary atresia is a disease in which bile flow is increasingly

Contact: Laurie Goodman
Journal of Clinical Investigation

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