HOME >> BIOLOGY >> NEWS
JCI table of contents, December 15, 2002

Find below one highlighted articles and the full Table of Contents for the December 16 issue.

Increased bone mass in a calcitonin knockout mouse full of surprises

Bone is in a constant state of remodeling, during which osteoclasts remove old bone (resorption) and osteoblasts form new bone (formation). Calcitonin is a hormone produced by the thyroid gland and inhibits bone resorption. Following menopause, the rate of bone loss is accelerated, however women with post-menopausal osteoporosis that are treated with calcitonin (by injection or nasal spray) demonstrate increased bone mass and strength, in addition to a decrease in the rate of bone fractures. Following alternative processing, the gene encoding calcitonin (CT/CGRP) also encodes a second peptide: calcitonin gene-related peptide-a (CGRPa), however the role of this peptide in bone metabolism has not been clearly defined.

To better understand the role of calcitonin and CGRP-a in bone metabolism Robert Gagel and colleagues at the University of Texas M.D. Anderson Cancer Center, USA, created mice in which the CT/CGRP gene had been deleted. Given that both calcitonin and CGRP have been shown to inhibit bone resorption and CGRP is known to stimulate bone formation, the authors predicted that there would be either no effect of this deletion on bone mass, or there could be some bone loss.

In the December 16 issue of the Journal of Clinical Investigation, the authors report their surprising finding that CT/CGRP-deficient mice have greater bone mass, increased bone formation, and were able to maintain bone mass during estrogen deficiency by increasing bone formation. These findings suggest an important and novel function for the products of the CT/CGRP gene, that was previously unrecognized. They also suggest that the development of an antagonist to the CT/CGRP gene product(s) may be useful in the prevention of bone loss associated wi
'"/>

Contact: Brooke Grindlinger, Ph.D.
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
17-Dec-2002


Page: 1 2 3 4 5 6 7 8

Related biology news :

1. Chemical engineering grad students will take notable national awards
2. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
3. JCI table of contents September 15, 2004
4. JCI table of contents: 1 September, 2004
5. Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
6. JCI table of contents, 16 August, 2004
7. JCI table of contents, 2 August, 2004
8. When male fish hum, females swim in, thanks to hormones, adaptable hearing
9. JCI table of contents, 1 July 2004
10. Search and destroy protein turns tables on HIV
11. JCI table of contents, 15 June 2004

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/9/2019)... and OAKLAND, Calif. (PRWEB) , ... March 07, ... ... allergy, food intolerance, and infectious disease diagnostics and automation – is pleased to ... an online quality control resource giving customers access to lot-specific information, including pattern ...
(Date:3/9/2019)... ... March 08, 2019 , ... Ace Laboratories, Inc. ... resveratrol + ribose hard candy lozenges ( http://www.well-mints.com ). , Well-Mints™ each contain ... hard candy base dusted with powdered sugar. , Well-Mints'™ patented technology delivers resveratrol ...
(Date:2/27/2019)... ALAMEDA, Calif. (PRWEB) , ... February 27, 2019 , ... ... today announced that it has received a National Cancer Institute grant for further development ... of 9 months, with clinical support from the lab of Dr. Omar Mian at ...
Breaking Biology News(10 mins):
(Date:3/5/2019)... ... March 05, 2019 , ... San Fransisko, or Sisko ... purchased him at four years old to pursue a career in dressage. According ... the most talented horse that she’d ever worked with. Unfortunately, Sisko suffered an ...
(Date:2/27/2019)... ... February 27, 2019 , ... Lajollacooks4u is pleased ... San Diego-based team-building and cooking events company will be offering a new cooking ... This fun-filled, interactive team-building event involves pairing two popular items together – tacos ...
(Date:2/22/2019)... ... February 20, 2019 , ... ... an emerging leader in the rapidly growing NGS (Next Generation Sequencing) field, have ... Genomics laboratory and incubator. , "As an innovation center and idea incubator, we ...
(Date:2/19/2019)... (PRWEB) , ... February 19, 2019 , ... VetStem ... regulatory and manufacturing experience. In October 2018, VetStem authorized the formation of Personalized ... to PSC its stem cell patents, data, and FDA filings to launch into human ...
Breaking Biology Technology:
Cached News: