HOME >> BIOLOGY >> NEWS
JCI table of contents, December 15, 2002

Find below one highlighted articles and the full Table of Contents for the December 16 issue.

Increased bone mass in a calcitonin knockout mouse full of surprises

Bone is in a constant state of remodeling, during which osteoclasts remove old bone (resorption) and osteoblasts form new bone (formation). Calcitonin is a hormone produced by the thyroid gland and inhibits bone resorption. Following menopause, the rate of bone loss is accelerated, however women with post-menopausal osteoporosis that are treated with calcitonin (by injection or nasal spray) demonstrate increased bone mass and strength, in addition to a decrease in the rate of bone fractures. Following alternative processing, the gene encoding calcitonin (CT/CGRP) also encodes a second peptide: calcitonin gene-related peptide-a (CGRPa), however the role of this peptide in bone metabolism has not been clearly defined.

To better understand the role of calcitonin and CGRP-a in bone metabolism Robert Gagel and colleagues at the University of Texas M.D. Anderson Cancer Center, USA, created mice in which the CT/CGRP gene had been deleted. Given that both calcitonin and CGRP have been shown to inhibit bone resorption and CGRP is known to stimulate bone formation, the authors predicted that there would be either no effect of this deletion on bone mass, or there could be some bone loss.

In the December 16 issue of the Journal of Clinical Investigation, the authors report their surprising finding that CT/CGRP-deficient mice have greater bone mass, increased bone formation, and were able to maintain bone mass during estrogen deficiency by increasing bone formation. These findings suggest an important and novel function for the products of the CT/CGRP gene, that was previously unrecognized. They also suggest that the development of an antagonist to the CT/CGRP gene product(s) may be useful in the prevention of bone loss associated wi
'"/>

Contact: Brooke Grindlinger, Ph.D.
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
17-Dec-2002


Page: 1 2 3 4 5 6 7 8

Related biology news :

1. Chemical engineering grad students will take notable national awards
2. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
3. JCI table of contents September 15, 2004
4. JCI table of contents: 1 September, 2004
5. Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
6. JCI table of contents, 16 August, 2004
7. JCI table of contents, 2 August, 2004
8. When male fish hum, females swim in, thanks to hormones, adaptable hearing
9. JCI table of contents, 1 July 2004
10. Search and destroy protein turns tables on HIV
11. JCI table of contents, 15 June 2004

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2020)... ... May 27, 2020 , ... Today ... , a solution that uniquely combines lab testing insights and hc1’s exclusive Local ... the ongoing health and safety of employees returning to the workplace. , “Some ...
(Date:5/26/2020)... ... May 26, 2020 , ... ... R&D, today announced that Gritstone Oncology, Inc., a clinical-stage biotechnology company developing ... engagers and TCR-based therapeutics, has implemented Genedata Biologics ® within their ...
(Date:5/21/2020)... CARY, N.C. (PRWEB) , ... ... ... Solutions , the leading software-as-a-service (SaaS) provider of operations management solutions, today ... new BioMed module provides a cloud-based platform for connecting the people and ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... July 09, 2020 , ... In most research using the ... pigment formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging. Over ... been using the zebrafish model to investigate the causes of leukaemia and its ...
(Date:7/1/2020)... (PRWEB) , ... June 29, 2020 , ... ... access to competitively procured purchasing contracts to its membership, recently named BioFit ... TIPS members with the opportunity to purchase ergonomic seating, cafeteria tables, book trucks ...
(Date:6/28/2020)... SPRING, Md. (PRWEB) , ... June 26, 2020 ... ... leading trade association representing security solutions providers, today announced its strong opposition to ... , The bill would impose a blanket ban on most federal use of ...
(Date:6/23/2020)... ... June 23, 2020 , ... Nobilis ... announced that it has filed an Investigational New Drug application (IND) with the ... of its lead drug candidate NBTX-001 in patients with panic disorder (PD). , ...
Breaking Biology Technology:
Cached News: