HOME >> BIOLOGY >> NEWS
JCI table of contents, February 2, 2004

1. Understanding the autoimmune response in type 1 diabetes

Type 1 diabetes mellitus (T1DM) is the result of immune-mediated destruction of insulin-secreting pancreatic beta cells. For more than 25 years researchers have searched for an environmental agent or event that triggers this autoimmune response. Past research has suggested that T cells that react to islet beta cells can contribute to the autoimmune response in diabetic patients and also play a part in self-tolerance in healthy individuals. The rarity of these cells and inadequate technology has impaired the examination of this paradigm. In the February 2 issue of the Journal of Clinical Investigation Mark Peakman and colleagues from King's College London suggest a mechanism for the specificity of this immune regulation that explains why the same peptides present on pancreatic b cells that activate T cells in patients with T1DM and normal individuals cause an autoimmune response in diabetic patients, but no such response in normal individuals.

The authors developed a novel assay to examine T cell responses to a panel of epitopes naturally expressed by islet cells and demonstrated that it is the pathways of T cell differentiation and maturation in reaction to these epitopes in T1DM patients (in whom autoimmunity develops) and normal individuals (in whom autoimmunity is arrested) that are different. Upon exposure to antigen, nave T cells in normal individuals differentiate into T cells that produce IL-10, and possibly TGF- beta, subsequently inhibiting cells that would normally mediate an aggressive immune response. The results reported by Peakman and colleagues suggest that in patients with T1DM, there is instead induction of a predominant number of T cells that produce IFN-gamma and IL-2, which drives an autoaggressive immune response. Why these T cell activation pathways differ between normal and T1DM patients will require further characterization.

In an accompanying commentar
'"/>

Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
2-Feb-2004


Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14

Related biology news :

1. Chemical engineering grad students will take notable national awards
2. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
3. JCI table of contents September 15, 2004
4. JCI table of contents: 1 September, 2004
5. Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
6. JCI table of contents, 16 August, 2004
7. JCI table of contents, 2 August, 2004
8. When male fish hum, females swim in, thanks to hormones, adaptable hearing
9. JCI table of contents, 1 July 2004
10. Search and destroy protein turns tables on HIV
11. JCI table of contents, 15 June 2004

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: JCI table contents February

(Date:4/22/2014)... from NeuroPhage Pharmaceuticals, Inc. have engineered a series ... neurodegenerative diseases that are characterized by misfolded proteins, ... molecules are based on what the Company calls ... recognizes a characteristic common to many toxic, misfolded ... This approach provides NeuroPhage with an array of ...
(Date:4/21/2014)... at The University of Texas at Dallas have ... carbon structures used in the manufacture of many ... Paul Pantano, associate professor of chemistry, and Dr. ... recently received a $459,000, three-year grant from the ... the National Institutes of Health, to track how ...
(Date:4/21/2014)... colleagues from Pittsburgh University, find how lipid mediators ... Nature Chemistry. Lipid mediators are molecules playing an ... to some of them has earned a Nobel ... "cellular power plants", the organelles where oxidation of ... (ATP), a molecule universally used for storage and ...
Breaking Biology News(10 mins):NeuroPhage discovers GAIM-changing molecules to combat Alzheimer's and related diseases 2NeuroPhage discovers GAIM-changing molecules to combat Alzheimer's and related diseases 3Grant to fund research on possible cell contaminants 2Grant to fund research on possible cell contaminants 3The anti-inflammatory factory 2The anti-inflammatory factory 3
(Date:1/15/2014)... ON (PRWEB) January 15, 2014 AudioNotch ... experimental new therapy for the treatment of tinnitus. Patients ... tinnitus frequency, and over a period of weeks to months, ... Sound Therapy in two forms: Notched Music and Notched White ...
(Date:1/14/2014)... Histogen, Inc., a regenerative medicine company ... under simulated embryonic conditions, today announced that they have ... Inc. for physician-dispensed aesthetic products containing Histogen’s proprietary multipotent ... is an amendment to the existing license between Histogen ...
(Date:1/14/2014)... Texas , Jan. 14, 2014 The ... and research medicinal plants and therapeutic derivatives thereof ... health professionals, and researchers about the challenges of ... http://photos.prnewswire.com/prnh/20100430/DC95601LOGO ) The Society ...
(Date:1/14/2014)... , Jan. 14, 2014  RXi Pharmaceuticals Corporation (OTCQX: ... and commercializing innovative therapies addressing major unmet medical ... received the Notice of Allowance from the United ... self-delivering RNAi compounds (sd-rxRNA®), for the treatment of ...
Breaking Biology Technology:Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3
Cached News: