tokine produced by innate immune and Th1 cells known to be involved in protective (type 1) immunity against bacterial infection. Zhou Xing and colleagues from McMaster University, Canada, and Institut Pasteur, France, sought to elucidate the role of this cytokine in the type 1 immune response by characterizing TNF-alphadeficient mice upon challenge with Mycobacterium bovis BCG. In the February 2 issue of the Journal of Clinical Investigation the authors report that mice deficient in TNF-alpha died upon pulmonary infection with myobacteria and suffered from an overactivation of the type 1 immune response as evidenced by expansion of CD4 and CD8 cells, increased frequency of antigen-specific T cells, overproduction of proimmune cytokines IFN-gamma and IL-12, and severe lung injury. Establishing TNF-alpha as a negative regulator of type 1 immunity has important implications for the development of therapeutic strategies that aim to block TNF-alpha.
TITLE: TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infection
McMaster University, Hamilton, Ontario, Canada.
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View the PDF of this article at: https://www.the-jci.org/press/18991.pdf
Glycoprotein 130: star of one signaling pathway with multiple outcomes for healthy bones
Mammalian skeletal growth and maintenance involves cooperation among bone formation, breakdown, and remodeling. Cytokines such as IL-6, dependent on glycoprotein 130 (gp130), are known to signal through at least 2 intracellular pathways: STAT1/3 and SHP2/ras/MAPK. However, the distinct downstream effects of these two pathways on bone development were previously unknown.
In the February 2 issue of the Journal of Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Related biology news :1
Contact: Brooke Grindlinger
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