y, Kevan Herald from the Naomi Berrie Diabetes Center at Columbia University, New York, comments that "these new findings concerning the responses of normal individuals and patients with T1DM to autoantigens shed light on the differences in immune responses between these two groups and the mechanisms of pathogenesis of the disease. The findings suggest ways in which regulation of the autoimmune response occur and offer approaches to immune modulation and ultimately tolerance, the immunologist's "Holy Grail."

TITLE: Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

AUTHOR CONTACT:
Mark Peakman
King's College London, London, United Kingdom.
Phone: 44-207-955-4656
Fax: 44-207-955-8894
E-mail: mark.peakman@kcl.ac.uk

View the PDF of this article at: https://www.the-jci.org/press/19585.pdf

ACCOMPANYING COMMENTARY: Achieving antigen-specific immune regulation

AUTHOR CONTACT:
Kevan C. Herold
Naomi Berrie Diabetes Center, Columbia University, New York, New York, USA.
Phone: (212) 305-3171
Fax: (212) 851-5493
E-mail: kh318@columbia.edu

View the PDF of this commentary at: https://www.the-jci.org/press/20963.pdf

---

2. Skin regeneration not isolated to epidermal stem cells

The outermost layer of the skin the epidermis is a rapidly renewing tissue and relies on the regenerative capacity of keratinocytes. Skin grafts using human cultured epidermal cells have been successful in treating patients with severe skin wounds. The notion that the ability to regenerate functional epidermal tissue is an exclusive property of epidermal stem cells is a general assumption in the stem cell biology field
'"/>

Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
2-Feb-2004

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