TITLE: Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery
AUTHOR CONTACT:
Jordan Gutterman
The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
Phone: 713-792-2676
Fax: 713-792-6554
E-mail: jgutterm@mdanderson.org
View the PDF of this article at: https://www.the-jci.org/press/18699.pdf
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Annexin II critical for angiogenesis
Endothelial cells are critical to the maintenance of hemostasis the balance of blood flow and clotting because they provide the site of assembly for a variety of regulatory factors, such as fibrin, involved in the response to vessel injury. Having generated annexin IInull mice in order to observe the physiologic roles of annexin II in hemostasis, Katherine Hajjar and colleagues from Cornell University in New York now show in the January 2 issue of the Journal of Clinical Investigation that annexin II does indeed participate in the regulation of fibrin homeostasis. The mice showed defective fibrinolytic function and impaired clearance of injury-induced arterial blood clots. Moreover, neoangiogenesis the formation of new blood vessels was abnormal in these mice, suggesting a key role for annexin II in activation of the vascularization process. This dual role in clotting and new vessel formation suggests that annexin II is an indispensable factor in hemostasis and a potential target for control of angiogenesis.
TITLE: Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo
AUTHOR CONTACT:
Katherine Hajjar
Weill Medical College of Cornell University, New York, New York, USA.
Phone: 212-746-2034
Fax: 212-746-8809
E-mail: khajjar@
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Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
2-Jan-2004