View the PDF of this article at: https://www.the-jci.org/press/19684.pdf
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Stat-3 preserves lung function during oxygen injury
Acute lung injury remains a common cause of morbidity and mortality in both adults and children, however the mechanisms regulating pulmonary homeostasis are poorly understood. In the January 2 issue of the Journal of Clinical Investigation, Jeffrey Whitsett and colleagues from Cincinnati Children's Hospital Medical Center investigated the role of the signaling molecule STAT-3 in lung injury. The Stat-3 gene was selectively deleted from the respiratory endothelial cells of mice. The deletion did not affect prenatal lung morphogenesis or post-natal lung function, however exposure of adult Stat-3deficient mice to 95% oxygen caused rapid, progressive lung injury, pulmonary capillary leakage, and respiratory distress. The report indicates that while Stat-3 is not required for lung formation it plays a critical role in the maintenance of lung function during oxygen injury.
TITLE: Stat-3 is required for pulmonary homeostasis during hyperoxia
AUTHOR CONTACT:
Jeffrey A. Whitsett
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Phone: 513-636-4830
Fax: 513-636-7868
E-mail: jeff.whitsett@cchmc.org
View the PDF of this article at: https://www.the-jci.org/press/19491.pdf
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The roles of growth hormone and IGF-1 in controlling insulin sensitivity
Insuling-like growth factor-1 (IGF-1) and growth hormone (GH) interact with insulin to modulate its control of carbohydrate metabolism. In the January 2 issue of the Journal of Clinical Investigation, Derek Le
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Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
2-Jan-2004