JCI table of contents, Janua...( Roith and colleagues from the National ...)

Roith and colleagues from the National Institutes of Health demonstrate that blocking the effect of GH in the presence of low serum IGF-1 concentrations enhances insulin sensitivity. This suggests that chronic elevation of GH levels plays a major role in insulin resistance. IGF-1 maintains the fine balance between insulin and GH in order to promote normal carbohydrate and lipid metabolism.

In an accompanying commentary David Clemmons from the University of North Carolina discusses insulin, GH, and IGF-1 regulation and how they affect food intake and insulin sensitivity.

TITLE: Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1deficient mice

AUTHOR CONTACT:
Derek LeRoith
National Institute of Diabetes and Digestive Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Phone: 301-496-8090
Fax: 301-480-4386
E-mail: derek@helix.nih.gov

View the PDF of this article at: https://www.the-jci.org/press/17763.pdf

ACCOMPANYING COMMENTARY: The relative roles of growth hormone and IGF-1 in controlling insulin sensitivity

AUTHOR CONTACT:
David R. Clemmons
University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Phone: 919-966-4735
Fax: 919-966-6025
E-mail: endo@medicineexch.med.unc.edu

View the PDF of this commentary at: https://www.the-jci.org/press/20660.pdf

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Ring around the rosy CTL

Cytotoxic T lymphocytes (CTLs) kill target cells by forming an immunological synapse with these cells. The CTLs and target cells adhere using the adhesion molecules LFA-1 and its counter-receptor ICAM-1. In the January 2 issue of th
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Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
2-Jan-2004

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