JCI table of contents, Janua...( one: 46-8-7287952 Fax: 46-8-332278 ...)

View the PDF of this article at: https://www.the-jci.org/press/19019.pdf

ACCOMPANYING COMMENTARY: Haldane, hot dogs, halitosis, and hypoxic vasodilation: the emerging biology of the nitrite anion

AUTHOR CONTACT:
Mark T. Gladwin
National Institutes of Health, Bethesda, Maryland, USA.
Phone: 301-435-2310
Fax: 301-402-1213
E-mail: mgladwin@nih.gov

View the PDF of this commentary at: https://www.the-jci.org/press/20664.pdf

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ONLINE FIRST ARTICLE

Distinct roles for VEGF isoforms in bone development

During bone formation, epiphyseal cartilage is avascular until secondary ossification occurs. Vascularization of this maturing tissue relies on angiogenic recruitment from surrounding vessels. The growth factorVEGF has previously been shown to be critical for metaphyseal bone vascularization and is now implicated as an angiogenic factor for epiphyseal vascularization. By generating mice that express specific splice forms of VEGF, Geert Carmeliet and colleagues from Katholike Universiteit Leuven, Belgium determined that the soluble forms of VEGF are indispensable for proper epiphyseal cartilage development, and chondrocyte development and survival. In the January 2 issue of the Journal of Clinical Investigation, Carmeliet et al. demonstrate that mice expressing only the matrix-bound form (VEGF188) but neither of the soluble forms (VEGF120 or VEGF164) had increased hypoxia and massive chondrocyte apoptosis in the epiphyseal cartilage, as well as dwarfed skeletal defects. Metaphyseal development appeared normal in th
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Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
2-Jan-2004