TITLE: Soluble VEGF isoforms are essential to establish epiphyseal vascularization and regulate chondrocyte development and survival
AUTHOR CONTACT:
Geert Carmeliet
Katholieke Universiteit Leuven, Leuven, Belgium
Phone: 32-16-345974
Fax: 32-16-345934
E-mail: geert.carmeliet@med.kuleuven.ac.be
View the PDF of this article at: https://www.the-jci.org/press/19383.pdf
**********************************************
**********************************************
Kaposi-sarcoma herpesvirus: a new paradigm for infection
Kaposi-sarcomaassociated herpesvirus (KSHV) infection is linked to the development of Kaposi sarcoma (KS). Other cancer-causing herpesviruses undergo lytic replication early in infection, which encompasses host cell infection, utilization of host cell machinery to manufacture virus, and host cell lysis to release new virus particles. These viruses then mature to a latent state, where infected host cells survive and the virus persists within them with little expression of its genes and without the production of progeny virus. In the case of KSHV, lytic replication is required throughout the entire natural history of infection in order to produce a KS lesion, however the reason for this is unknown. Current theories have suggested that lytically infected cells secrete substances that promote angiogenesis and inflammation: hallmarks of KS. In the January 2 issue of the Journal of Clinical Investigation, Don Ganem and colleagues from the University of California, San Francisco demonstrate that latency in KSHV is unstable and results in segregation of the viral episome. The data indicate that acquisition of stable KSHV laten
'"/>
Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
2-Jan-2004