In an accompanying commentary, Bill Sugden and Chen-Yu Wang from the University of Wisconsin-Madison discuss the contribution of the lytic cycle to oncogenesis and how this finding impacts our current understanding of herpesvirus infection.
TITLE: Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis
AUTHOR CONTACT:
Don E. Ganem
Howard Hughes Medical Institute, and Department of Microbiology, University of California San Francisco, San Francisco, California, USA.
Phone: 415-476-2826
Fax: 415-476-0939
E-mail: ganem@cgl.ucsf.edu
View the PDF of this article at: https://www.the-jci.org/press/17803.pdf
ACCOMPANYING COMMENTARY: New viruses shake old paradigms
AUTHOR CONTACT:
Bill Sugden
University of Wisconsin, Madison, Wisconsin, USA.
Phone: 608-262-6697
Fax: 608-262-2824
E-mail: sugden@oncology.wisc.edu
View the PDF of this commentary at: https://www.the-jci.org/press/20662.pdf
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Caspase-3 activation triggers muscle breakdown
Loss of muscle mass is a serious consequence of catabolic conditions such as cancer, uremia, sepsis, and diabetes. However the initial step in this breakdown process is unknown. As cytokines or insulin resistance activate caspases, and are common in catabolic states, William Mitch and colleagues from the Univ
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Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
2-Jan-2004