JCI table of contents, Janua...( authors found that hepatic cell death w...)

authors found that hepatic cell death was dramatically reduced in TRAIL-deficient mice as well as in mice in which the TRAIL receptor was blocked. Restoration of TRAIL activity restored the sensitivity of TRAIL-deficient mice to hepatitis. The report demonstrates that TRAIL plays a crucial role in hepatic cell death and liver inflammation. While further investigation is needed to comprehensively understand the in vivo functions of TRAIL, the safety and potential side effects of TRAIL-based cancer therapy in humans remain unresolved.

TITLE: Critical roles of TRAIL in hepatic cell death and hepatic inflammation

AUTHOR CONTACT:
Youhai Chen
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Phone: 215-898-4671
Fax: 215-573-8606
E-mail: yhc@mail.med.upenn.edu

View the PDF of this article at: https://www.the-jci.org/press/19255.pdf

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Male/female differences in diabetic stroke recovery

Diabetic hyperglycemia is a recognized risk factor for stroke and increases brain damage after cerebral ischemia. The underlying mechanisms remain unclear but may involve increased apoptosis. While previous studies showed female diabetic mice suffered less brain damage following cerebral hypoxia-ischemia than male diabetic mice, Susan Vannucci and colleagues from Columbia University in New York investigated the effects of estrogen, an established neuroprotectant, on ischemic recovery. Female diabetic and nondiabetic mice had their ovaries removed via ovariectomy and were treated with estrogen replacement, or a control, prior to hypoxia. In the January 2 issue of the Journal of Clinical Investigation, Vannucci and colleagues report that ovariectomy increased ischemic damage in nondiabetic mice, and estrogen replacement reduced tissue injury
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Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
2-Jan-2004

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