Cell Biology in Sydney, Australia, have identified a novel function for BAFF: it acts as a specific survival factor for Ig-secreting cells derived from memory B cells. The study suggest that in human autoimmune diseases, elevated levels of serum BAFF may contribute to the disease process by not only breaking tolerance at the immature/transitional B cell stage of development, but by also enhancing plasmablast survival.

TITLE: BAFF selectively enhances the survival of plasmablasts generated from human memory B cells

AUTHOR CONTACT:
Stuart Tangye
Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia.
Phone: 61-2-9565-6127
Fax: 61-2-9565-6103
E-mail: s.tangye@centenary.usyd.edu.au

View the PDF of this article at: https://www.the-jci.org/press/18025.pdf

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Secret to controlling thyroid hormone production

Originating in the thyroid, the prohormone thyroxine is converted to triiodothyronine, which is essential in brain development, growth, and metabolism. A study from researchers at Brigham and Women's Hospital in Boston, reveals a novel mechanism for controlling triiodothyronine production that demonstrates the first example of enzyme activity being restored by deubiquitination.

TITLE: Deubiquitination of type 2 iodothyronine deiodinase by von HippelLindau proteininteracting deubiquitinating enzymes regulates thyroid hormone activation

AUTHOR CONTACT:
Antonio C. Bianco
Harvard University, Boston, Massachusetts, USA.
Phone: 617-525-5153
Fax: 617-731-4718
E-mail: abianco@partners.org

View the PDF of this article at: https://www.the-jci.org/press/18348.pdf

ACCOMPANYING COMMENTARY:
Ubiquitinated dei
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Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
15-Jul-2003

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