William E. Carson III
The Ohio State University, Columbus, Ohio, USA.
View the PDF of this article at: https://www.the-jci.org/press/16603.pdf
Another piece of the puzzle by which insulin controls blood sugar and fat mass
The serine/threonine kinase Akt/PKB has three mammalian isoforms: Akt1 (PKBa), Akt2 (PKBb), and Akt3 (PKBg). The three isoforms show broad tissue distribution, with the Akt2 isoform predominating in insulin-responsive tissues. Researchers at Pfizer have now generated Akt2 knockout (KO) mice that show similar growth retardation to that previously reported in Akt1 KO mice. The Akt2 KO mice exhibit impaired glucose metabolism, pancreatic b cell failure, and loss of fat mass, which were not previously reported in mice lacking Akt1. The authors conclude that both Akt1 and Akt2 play a role in the regulation of growth, but only Akt2 regulates glucose metabolism and fatty tissue mass. In addition, Akt2 is critical for the adaptive response of pancreatic b cells to insulin resistance and hyperglycemia.
TITLE: Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBb
Robert S. Garofalo
Pfizer Global Research and Development, Groton, Connecticut, USA.
View the PDF of this article at: https://www.the-jci.org/press/16885.pdf