The Latest Biology News And Medical NewsBiology News 2Health News 2Biology News 3Health News 3
HOME >> BIOLOGY >> NEWS
JCI table of contents, March 1 2004

Vaccine nips breast cancer in the bud

Preneoplastic lesions, detectable by breast cancer screening, are made up of altered cells that are not themselves cancerous but indicate an increased likelihood that a benign or cancerous tumor may subsequently form. In the March 1 issue of the Journal of Clinical Investigation, Federica Cavallo and colleagues from the University of Turin, Italy, evaluated vaccine strategies for treating neoplastic lesions. The authors designed a combined approach consisting of a primary vaccination with plasmids encoding portions of the oncogenic protein rp185neu and a booster vaccination one week later with cells expressing this protein and also engineered to release IFN-gamma. Of mice that received the combined vaccine, 48% remained tumor free for the duration of the study, a significant improvement over untreated mice and mice receiving only the primary vaccine. Both morphologic analysis of the lesions and microarray analysis of gene expression in parallel revealed that the immune reaction halted carcinogenesis and reverted neoplastic lesions to an early stage. This study highlights the potential of a combinatorial approach to vaccination for the prevention and suppression of neoplastic lesions.

TITLE: Concordant morphologic and gene expression data show that a vaccine halts HER-2/neu preneoplastic lesions

AUTHOR CONTACT:
Federica Cavallo
University of Turin, Orbassano, Italy.
Phone: 39 11-670-8119
Fax: 39-11-236-8117
E-mail: federica.cavallo@unito.it

View the PDF of this article at: https://www.the-jci.org/press/19850.pdf

**********************************************

Gene therapy for a broken heart

Despite significant ad-vances in the treatment of cardiac disease, chronic heart failure remains a leading cause of morbidity and mortality. Gene
'"/>

Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
1-Mar-2004


Page: 1 2 3 4 5 6 7 8 9 10 11 12 13

Related biology news :

1. Chemical engineering grad students will take notable national awards
2. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
3. JCI table of contents September 15, 2004
4. JCI table of contents: 1 September, 2004
5. Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
6. JCI table of contents, 16 August, 2004
7. JCI table of contents, 2 August, 2004
8. When male fish hum, females swim in, thanks to hormones, adaptable hearing
9. JCI table of contents, 1 July 2004
10. Search and destroy protein turns tables on HIV
11. JCI table of contents, 15 June 2004

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: JCI table contents March

(Date:11/24/2009)...llege of Medical Toxicology (ACMT) have signed an ... Journal of Medical Toxicology (JMT), the offici...It was previously published by the University of P...xicology , an international, peer-reviewed journal...ce of medical toxicology. The quarterly journal f...
(Date:11/24/2009)...n Spanish . , The presence of increased bod... substances in the blood, hinders the loss and mai...oject of the University of Navarra conducted by Es...of Pharmacy. , The project, entitled "A nutrigen...trol of body weight and inflammation," examines ho...
(Date:11/23/2009)...e Conservation Society says that western lowland g... Congopart of the "mother lode" of more than 125,0...asingly threatened by growing humans activity in t...the swamp forests adjacent to the southwest border...confirmed that high densities of the great apes st...
Breaking Biology News(10 mins):Springer and the American College of Medical Toxicology to work together 2It can be predicted the reaction obese patients will have to a diet 2A year after discovery, Congo's 'mother lode' of gorillas remains vulnerable 2Chemist receives NIH New Innovator grant for genetic drug research 10360 1Chemist receives NIH New Innovator grant for genetic drug research 10360 2MSU becoming center of excellence for Parkinsons research 10356 1MSU becoming center of excellence for Parkinsons research 10356 2Stem Cells Being Tested to Fight Pancreatic Cancer 59455 1Stem Cells Being Tested to Fight Pancreatic Cancer 59455 2
(Date:11/24/2009)...IM,Ontario,Nov.24/PRNewswire-FirstCall/--DowAgroSc...HylandSeeds,adivisionofThompsonsLimitedofBlenheim,...owAgroSciences,currentseedsbusinessasthecompanyant...andDowAgroSciencesHerbicideTolerantTraitTechnology...earfuture. ,, "Thisacquisitionbringstogethertwo...
(Date:11/24/2009)...d,November24/PRNewswire-FirstCall/--deCODE,genetic...lofits,"firstday"motionsbytheU.S.BankruptcyCourtfo...DElastweekfiledavoluntarypetitionfor,reliefunderCh...ruptcyCourt. , TheordersissuedbytheBankruptcy...sduringtheChapter11proceedings.Inparticular,the,co...
(Date:11/24/2009)...RNewswire/--BlueMarbleEnergyCorp.announcedtodaytha...OPDA)wererecentlyawarded$2millionbyWashingtonState...vate/publicpartnershiptoconstructthestate,sfirstsp..., "Thisinvestmentwillsignificantlyspeedthedevel...colnCounty,"saidBlueMarbleEnergyCEOKellyOgilvie."W...
(Date:11/24/2009)...4/PRNewswire-FirstCall/--Shireplc(LSE:SHP,NASDAQ:...y,today,announcedthatithassubmittedaMAAtotheEurope...senzymereplacementtherapyindevelopment,forthetreat...applicationforvelaglucerasealfathathasbeensubmitte...da. , Basedonaglobalsupplyshortageofthecurren...
Breaking Biology Technology:Dow AgroSciences Canada Announces Agreement to Acquire Hyland Seeds 2Dow AgroSciences Canada Announces Agreement to Acquire Hyland Seeds 3deCODE genetics, Inc. Announces Approval of First Day Motions by Bankruptcy Court 2deCODE genetics, Inc. Announces Approval of First Day Motions by Bankruptcy Court 3Blue Marble Energy, OPDA Awarded $2M by WA's Community Economic Revitalization Board 2Shire Submits European Marketing Authorization Application (MAA) for velaglucerase alfa for the Treatment of Type 1 Gaucher Disease 2Shire Submits European Marketing Authorization Application (MAA) for velaglucerase alfa for the Treatment of Type 1 Gaucher Disease 3
Other News:
...s medical elite will come to Pittsburgh August 20-...e and discuss some of the latest technologies used... to improve patient care. The symposium, co-sponso...imulate increased interaction among academic clini...
...r as a result of global warming, according to a ne...d the Carnegie Institution of Washington. This sur...e National Academy of Sciences (PNAS), contradicts...mperatures could dry out natural landscapes, inclu...
WEST LAFAYETTE, Ind. - It may be a right-handed world, but recent Purdue University research indicates that the first building blocks of life were lefties - and suggests why, on a molecular level, all
...sively, especially during the last decade. Today ...he Colorado River in North America, no longer reac...r Alan Covich (Institute of Ecology University of...th of University of Georgia Tifton) recount the re...
Another global warming surprise: Grasslands may become wetter as temperatures rise 2Another global warming surprise: Grasslands may become wetter as temperatures rise 3Purdue scientists discover why we're all lefties deep down 2Purdue scientists discover why we're all lefties deep down 3Drought 2
...ked up nose that stops you smelling chimney smoke,...he other seasonal scents. Now researchers funded b...ch Council (BBSRC) have not only discovered how ai... but their work may lead to new ways of unblocking...
... Thirty-eight US Oncology, Inc. (NASDAQ:USON) aff...y a significant role in the clinical research of A...nd Drug Administration (FDA). ABRAXANETM (paclita...ion), a next generation taxane, and the first in a...
...view of planet Earth, and the space-based vantage ...ewing out-of-the-way places. Conservationists, for...protection. Wars, poverty, remoteness, lack of gov... places and ways to focus limited resources can al...
...Chunying Du, Ph.D., Assistant Investigator at the ...eal a previously unknown pathway of Bruce, the gen...rogrammed cell death.......The findings are availa...1 and will be published in the Jan. 18 issue of Pr...
Scientists find that the human nose is more complicated than a jumbo jet 2US Oncology, Inc. plays role in newly approved ABRAXANE for metastatic breast cancer 2US Oncology, Inc. plays role in newly approved ABRAXANE for metastatic breast cancer 3Gorillas in the midst of extinction 2Stowers researcher answers fundamental question of cell death 2