HOME >> BIOLOGY >> NEWS
Jackson researchers identify a gene implicated in oxidative stress and neurodegeneration

Oxidative stress is implicated in a fast-growing list of human conditions, from the superficial (e.g., wrinkled skin) to the deadly: diseases such as cancer, heart disease and neurodegenerative disorders including Lou Gehrig's disease (amyotrophic lateral sclerosis or ALS).

Researchers at The Jackson Laboratory announced that they have located a gene that protects certain brain and retinal neurons from oxidative stress, and prevents neurodegeneration.

Many normal metabolic functions produce free radicals--highly unstable forms of oxygen. Despite their notoriety, these molecules in fact have several beneficial roles, such as helping white blood cells attack bacteria, viruses and virus-damaged cells. Oxidative stress occurs when the amount of free radicals exceeds the normal antioxidant capacity of a cell, leading to cell damage.

The research team, headed by Staff Scientist Susan Ackerman, Ph.D., discovered that mice from a strain called harlequin have a mutation in the apoptosis-inducing factor (Aif) gene, causing a severe reduction in AIF production. The AIF protein serves as a scavenger of free radicals in certain brain and retinal neurons. Because harlequin mice have much lower levels of AIF, neurons in these mice undergo oxidative stress. The researchers demonstrate that oxidative stress causes neurons to duplicate their DNA in a process known as re-entering the cell cycle. But the neurons cannot successfully divide. They die in the attempt.

The results of Dr. Ackerman's team's work, published in the journal Nature, provide a genetic model of neurodegeneration mediated by oxidative stress. They also demonstrate a direct connection between cell cycle re-entry and oxidative stress in an aging central nervous system.

To date, ALS is the one neurodegenerative disorder known to be caused by oxidative damage to neurons. However, oxidative stress has been identified as a possible cause of several later-onset neurodegenerative diseas
'"/>

Contact: Joyce Peterson
joyce@jax.org
207-288-6058
Jackson Laboratory
25-Sep-2002


Page: 1 2

Related biology news :

1. $14 Million NIH grant launches heart, lung, blood and sleep disorders center at the Jackson Laboratory
2. Mayo Clinic Jacksonville scientists show that specially created molecules can cross blood-brain barrier
3. Jackson Laboratory Researchers Identify Neuromuscular Degeneration Gene
4. Alstrom Syndrome Genetics Studied At Jackson Laboratory
5. Belgian researchers explore revolutionary approach to angiogenesis
6. Award winning researchers reveal potential new role for Glivec
7. $7.5 Million grant to Yale researchers for role of viruses in cancer
8. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
9. Joslin researchers clarify mechanisms for beta-cell formation
10. Virginia Tech researchers to release findings on Smith River Project
11. Molecular motor myosin VI moves hand over hand, researchers say

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/26/2016)... , April 27, 2016 ... the  "Global Multi-modal Biometrics Market 2016-2020"  report to ... ) , The analysts forecast the ... CAGR of 15.49% during the period 2016-2020.  ... number of sectors such as the healthcare, BFSI, ...
(Date:4/13/2016)... April 13, 2016  IMPOWER physicians supporting Medicaid patients ... a new clinical standard in telehealth thanks to a ... the higi platform, IMPOWER patients can routinely track key ... body mass index, and, when they opt in, share ... visit to a local retail location at no cost. ...
(Date:3/22/2016)... March 22, 2016 ... Sensors Market for Consumer Industry by Type (Image, ... Application (Communication & IT, Entertainment, Home Appliances, ... Forecast to 2022", published by MarketsandMarkets, the ... to reach USD 26.76 Billion by 2022, ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... CLEVELAND , June 27, 2016  Global ... average 4.6 percent through 2020 to $7.2 billion.  ... (food and beverages, cleaning products, biofuel production, animal ... and biotechnology, diagnostics, and biocatalysts). Food and beverages ... gains driven by increasing consumption of products containing ...
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... to bring innovative medical technologies, services and solutions to the healthcare market. The ... implementation of various distribution, manufacturing, sales and marketing strategies that are necessary to ...
(Date:6/24/2016)... , June 24, 2016 Epic Sciences ... detects cancers susceptible to PARP inhibitors by targeting ... cells (CTCs). The new test has already been ... in multiple cancer types. Over 230 ... damage response pathways, including PARP, ATM, ATR, DNA-PK ...
(Date:6/23/2016)... CAMBRIDGE, Mass. , June 23, 2016 /PRNewswire/ ... the development of novel compounds designed to target ... compound, napabucasin, has been granted Orphan Drug Designation ... in the treatment of gastric cancer, including gastroesophageal ... cancer stemness inhibitor designed to inhibit cancer stemness ...
Breaking Biology Technology:
Cached News: