HOME >> BIOLOGY >> NEWS
Jackson researchers identify a gene implicated in oxidative stress and neurodegeneration

Oxidative stress is implicated in a fast-growing list of human conditions, from the superficial (e.g., wrinkled skin) to the deadly: diseases such as cancer, heart disease and neurodegenerative disorders including Lou Gehrig's disease (amyotrophic lateral sclerosis or ALS).

Researchers at The Jackson Laboratory announced that they have located a gene that protects certain brain and retinal neurons from oxidative stress, and prevents neurodegeneration.

Many normal metabolic functions produce free radicals--highly unstable forms of oxygen. Despite their notoriety, these molecules in fact have several beneficial roles, such as helping white blood cells attack bacteria, viruses and virus-damaged cells. Oxidative stress occurs when the amount of free radicals exceeds the normal antioxidant capacity of a cell, leading to cell damage.

The research team, headed by Staff Scientist Susan Ackerman, Ph.D., discovered that mice from a strain called harlequin have a mutation in the apoptosis-inducing factor (Aif) gene, causing a severe reduction in AIF production. The AIF protein serves as a scavenger of free radicals in certain brain and retinal neurons. Because harlequin mice have much lower levels of AIF, neurons in these mice undergo oxidative stress. The researchers demonstrate that oxidative stress causes neurons to duplicate their DNA in a process known as re-entering the cell cycle. But the neurons cannot successfully divide. They die in the attempt.

The results of Dr. Ackerman's team's work, published in the journal Nature, provide a genetic model of neurodegeneration mediated by oxidative stress. They also demonstrate a direct connection between cell cycle re-entry and oxidative stress in an aging central nervous system.

To date, ALS is the one neurodegenerative disorder known to be caused by oxidative damage to neurons. However, oxidative stress has been identified as a possible cause of several later-onset neurodegenerative diseas
'"/>

Contact: Joyce Peterson
joyce@jax.org
207-288-6058
Jackson Laboratory
25-Sep-2002


Page: 1 2

Related biology news :

1. $14 Million NIH grant launches heart, lung, blood and sleep disorders center at the Jackson Laboratory
2. Mayo Clinic Jacksonville scientists show that specially created molecules can cross blood-brain barrier
3. Jackson Laboratory Researchers Identify Neuromuscular Degeneration Gene
4. Alstrom Syndrome Genetics Studied At Jackson Laboratory
5. Belgian researchers explore revolutionary approach to angiogenesis
6. Award winning researchers reveal potential new role for Glivec
7. $7.5 Million grant to Yale researchers for role of viruses in cancer
8. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
9. Joslin researchers clarify mechanisms for beta-cell formation
10. Virginia Tech researchers to release findings on Smith River Project
11. Molecular motor myosin VI moves hand over hand, researchers say

Post Your Comments:
(Date:6/24/2015)... Switzerland , June 24, 2015 ... partnership with emerging biometric password solution one face ... one face in, entering ... a ground-breaking and affordable multifactor-authentication biometric answer to ... recognition technology, provided in partnership with KeyLemon, one ...
(Date:6/18/2015)... NEW YORK , June 18, 2015 ... in US$ Million by the following Product Segments, which ... Immunoassay Systems, Chemiluminescence Immunoassay Systems, Radio Immunoassay Systems, and ... for the US, Canada , ... Asia-Pacific , Latin America ...
(Date:6/17/2015)... Fla. , June 17, 2015  Crossmatch™, ... today announced that its U.are.U ® 4500 ... Togo,s Eateries, Inc., a ... sandwich chain, to increase security, improve accountability and ... readers enable instant, non-repudiable identity confirmation for employee ...
Breaking Biology News(10 mins):KeyLemon Announces Partnership With Biometric Password Solution onefacein 2Global Immunoassay Systems Market 2Global Immunoassay Systems Market 3Global Immunoassay Systems Market 4Global Immunoassay Systems Market 5Global Immunoassay Systems Market 6Global Immunoassay Systems Market 7Global Immunoassay Systems Market 8Global Immunoassay Systems Market 9Global Immunoassay Systems Market 10Global Immunoassay Systems Market 11Global Immunoassay Systems Market 12Global Immunoassay Systems Market 13Global Immunoassay Systems Market 14Global Immunoassay Systems Market 15Global Immunoassay Systems Market 16Global Immunoassay Systems Market 17Global Immunoassay Systems Market 18Global Immunoassay Systems Market 19Global Immunoassay Systems Market 20Global Immunoassay Systems Market 21Global Immunoassay Systems Market 22Global Immunoassay Systems Market 23Global Immunoassay Systems Market 24Global Immunoassay Systems Market 25Global Immunoassay Systems Market 26Global Immunoassay Systems Market 27Global Immunoassay Systems Market 28Global Immunoassay Systems Market 29Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3
(Date:7/1/2015)... (PRWEB) , ... July 01, 2015 , ... It is ... injury (TBI) using single photon emission computed tomography (SPECT) according to researchers ... study, which examined over 20,000 brain scans and is believed to be the largest ...
(Date:7/1/2015)... July 1, 2015   Neuraltus Pharmaceuticals, Inc. ... of groundbreaking drugs to treat neurodegenerative diseases such ... Robert G. Miller , M.D., Director of the ... California Pacific Medical Center in San Francisco, has been ... $1.5 million to help fund a Phase 2 ...
(Date:7/1/2015)... IN (PRWEB) , ... July 01, 2015 , ... Apex ... 2015 BIO International Convention in Philadelphia, PA. , The presentation took place ... and outlined the plans for the development of APX3330 for the treatment of pancreatic ...
(Date:6/30/2015)... , June 30, 2015 /PRNewswire/ - Resverlogix ... of common shares of Resverlogix have approved the ... Eastern Capital Limited of 5,600,000 units at a ... Placement"), each unit being comprised of one common ... aggregate proceeds of approximately CAD$15 million; and (ii) ...
Breaking Biology Technology:Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 4Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 2Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 4Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 2Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 3
Cached News: