Jackson researchers identify a gene implicated in oxidative stress and neurodegeneration

Oxidative stress is implicated in a fast-growing list of human conditions, from the superficial (e.g., wrinkled skin) to the deadly: diseases such as cancer, heart disease and neurodegenerative disorders including Lou Gehrig's disease (amyotrophic lateral sclerosis or ALS).

Researchers at The Jackson Laboratory announced that they have located a gene that protects certain brain and retinal neurons from oxidative stress, and prevents neurodegeneration.

Many normal metabolic functions produce free radicals--highly unstable forms of oxygen. Despite their notoriety, these molecules in fact have several beneficial roles, such as helping white blood cells attack bacteria, viruses and virus-damaged cells. Oxidative stress occurs when the amount of free radicals exceeds the normal antioxidant capacity of a cell, leading to cell damage.

The research team, headed by Staff Scientist Susan Ackerman, Ph.D., discovered that mice from a strain called harlequin have a mutation in the apoptosis-inducing factor (Aif) gene, causing a severe reduction in AIF production. The AIF protein serves as a scavenger of free radicals in certain brain and retinal neurons. Because harlequin mice have much lower levels of AIF, neurons in these mice undergo oxidative stress. The researchers demonstrate that oxidative stress causes neurons to duplicate their DNA in a process known as re-entering the cell cycle. But the neurons cannot successfully divide. They die in the attempt.

The results of Dr. Ackerman's team's work, published in the journal Nature, provide a genetic model of neurodegeneration mediated by oxidative stress. They also demonstrate a direct connection between cell cycle re-entry and oxidative stress in an aging central nervous system.

To date, ALS is the one neurodegenerative disorder known to be caused by oxidative damage to neurons. However, oxidative stress has been identified as a possible cause of several later-onset neurodegenerative diseas

Contact: Joyce Peterson
Jackson Laboratory

Page: 1 2

Related biology news :

1. $14 Million NIH grant launches heart, lung, blood and sleep disorders center at the Jackson Laboratory
2. Mayo Clinic Jacksonville scientists show that specially created molecules can cross blood-brain barrier
3. Jackson Laboratory Researchers Identify Neuromuscular Degeneration Gene
4. Alstrom Syndrome Genetics Studied At Jackson Laboratory
5. Belgian researchers explore revolutionary approach to angiogenesis
6. Award winning researchers reveal potential new role for Glivec
7. $7.5 Million grant to Yale researchers for role of viruses in cancer
8. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
9. Joslin researchers clarify mechanisms for beta-cell formation
10. Virginia Tech researchers to release findings on Smith River Project
11. Molecular motor myosin VI moves hand over hand, researchers say

Post Your Comments:

(Date:4/15/2016)... Research and Markets has announced ... 2016-2020,"  report to their offering.  , ... global gait biometrics market is expected to grow ... 2016-2020. Gait analysis generates multiple variables ... to compute factors that are not or cannot ...
(Date:3/31/2016)... , March 31, 2016  Genomics firm Nabsys ... founding CEO, Barrett Bready , M.D., who returned ... of the original technical leadership team, including Chief Technology ... of Product Development, Steve Nurnberg and Vice President of ... to the company. Dr. Bready served as ...
(Date:3/22/2016)... , PROVO and ... Newborn Screening Ontario (NSO), which operates the highest sample ... molecular testing, and Tute Genomics and UNIConnect, leaders in ... respectively, today announced the launch of a project to ... (NGS) testing panel. NSO has been ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... June 24, 2016  Regular discussions on a range of ... between the two entities said Poloz. Speaking at ... Ottawa , he pointed to the country,s inflation target, ... government. "In certain ... institutions have common economic goals, why not sit down and ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... is pleased to announce the launch of their brand, UP4™ Probiotics, into Target ... over 35 years, is proud to add Target to its list of well-respected ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm ... Mold) microbial test has received AOAC Research Institute approval 061601. , “This is ... last year,” stated Bob Salter, Vice President of Regulatory and Industrial Affairs. “The ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample ... the Arkansas State Crime Laboratory, has joined STACS DNA as a Field Application Specialist. ... said Jocelyn Tremblay, President and COO of STACS DNA. “In further expanding our capacity ...
Breaking Biology Technology:
Cached News: