HOME >> BIOLOGY >> NEWS
Jefferson Researchers Find Correlation Between Gene And Endometrial Cancer

Researchers at Jefferson Medical College have found that the less a particular "protective" gene is present in endometrial cancer cells, the more aggressive the disease will be, and the greater the likelihood the woman will die from the disease. The finding may eventually lead to a test that can predict disease severity and help guide treatment.

Antonio Giordano, M.D., Ph.D., associate professor of pathology, anatomy and cell biology at Thomas Jefferson University, in Philadelphia and his colleagues there and at the University of Florence and at the Second University of Naples examined the cancer cells of 100 patients who underwent surgery for endometrial cancer. The patients had no prior radiation or chemotherapy.

They found that five years after surgery, lower levels of the tumor suppressor gene Rb2/p130 correlated with a higher risk than normal of returning disease. The women were also more likely to die of the cancer. They report their findings in the March issue of the Journal of Clinical Oncology.

"We measured Rb2/p130 status in relation to the length of disease-free survival and disease-specific survival in 100 endometrial cancer patients who had surgery to remove the tumor," explains Dr. Giordano, who also is president of the Sbarro Institute for Cancer Research and Molecular Medicine, which is affiliated with Jefferson Medical College. "We found a decreased level of pRb2 in endometrial cancer significantly associated with decreased probability of remaining disease-free.

"We found that the risk of dying from endometrial cancer was four and a half times more likely in women with these lower levels of the gene," he points out. "In patients with endometrial cancer, and who haven’t had chemotherapy or radiation before surgery, the presence of Rb2 is associated with a higher risk of dying independent
'"/>

Contact: Steve Benowitz
steven.benowitz@mail.tju.edu
215-955-6300
Thomas Jefferson University
26-Feb-1998


Page: 1 2 3

Related biology news :

1. Jefferson Lab detector technology aids development of cystic fibrosis therapy
2. Jefferson scientists find gene expression pattern may predict behavior of leukemia
3. Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue
4. Jefferson scientists use gene therapy to restore function of damaged heart cells in lab
5. Jefferson researchers uncover biochemical clues to how cells migrate in embryos
6. Jefferson and Brigham and Womens researchers find blue light important for setting biological clock
7. Jefferson Lab experiment generates THz radiation 20,000 times brighter than anyone else
8. Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory
9. Jefferson scientists show how collagen gene mutation leads to osteoarthritis
10. Jefferson scientists use gene repair technique to change albino mice hairs to black
11. Jefferson scientists show drug is effective against a Hepatitis C Virus model in the laboratory

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/30/2017)... , June 30, 2017 Today, American ... and supplier of face and eye tracking software, ... Product provider program. "Artificial intelligence ... way to monitor a driver,s attentiveness levels while ... being able to detect fatigue and prevent potential ...
(Date:5/23/2017)... -- Hunova, the first robotic gym for the rehabilitation and functional motor sense ... Genoa, Italy . The first 30 robots will be available ... USA . The technology was developed and patented at the IIT ... Movendo Technology thanks to a 10 million euro investment from entrepreneur Sergio ... ...
(Date:5/6/2017)... 2017 RAM Group , Singaporean ... breakthrough in biometric authentication based on a ... to perform biometric authentication. These new sensors are based ... by Ram Group and its partners. This sensor will ... chains and security. Ram Group is a next ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... Market with the addition of its newest module, US Hemostats & Sealants. , ... thrombin hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic sealants used in ...
(Date:10/11/2017)... ... 11, 2017 , ... Personal eye wash is a basic first aid supply for any work ... which eye do you rinse first if a dangerous substance enters both eyes? It’s one ... with its unique dual eye piece. , “Whether its dirt and debris, or an ...
(Date:10/11/2017)... Tbilisi, Georgia (PRWEB) , ... October 11, 2017 , ... ... disaster, taking the lives of over 5.5 million people each year. Especially those living ... the greenovative startup Treepex - based in one of the most pollution-affected countries globally ...
(Date:10/10/2017)... , ... October 10, 2017 , ... ... Center’s FirstHand program has won a US2020 STEM Mentoring Award. Representatives of the ... for Excellence in Volunteer Experience from US2020. , US2020’s mission is to change ...
Breaking Biology Technology:
Cached News: