HOME >> BIOLOGY >> NEWS
Jefferson Researchers Find Correlation Between Gene And Endometrial Cancer

Researchers at Jefferson Medical College have found that the less a particular "protective" gene is present in endometrial cancer cells, the more aggressive the disease will be, and the greater the likelihood the woman will die from the disease. The finding may eventually lead to a test that can predict disease severity and help guide treatment.

Antonio Giordano, M.D., Ph.D., associate professor of pathology, anatomy and cell biology at Thomas Jefferson University, in Philadelphia and his colleagues there and at the University of Florence and at the Second University of Naples examined the cancer cells of 100 patients who underwent surgery for endometrial cancer. The patients had no prior radiation or chemotherapy.

They found that five years after surgery, lower levels of the tumor suppressor gene Rb2/p130 correlated with a higher risk than normal of returning disease. The women were also more likely to die of the cancer. They report their findings in the March issue of the Journal of Clinical Oncology.

"We measured Rb2/p130 status in relation to the length of disease-free survival and disease-specific survival in 100 endometrial cancer patients who had surgery to remove the tumor," explains Dr. Giordano, who also is president of the Sbarro Institute for Cancer Research and Molecular Medicine, which is affiliated with Jefferson Medical College. "We found a decreased level of pRb2 in endometrial cancer significantly associated with decreased probability of remaining disease-free.

"We found that the risk of dying from endometrial cancer was four and a half times more likely in women with these lower levels of the gene," he points out. "In patients with endometrial cancer, and who haven’t had chemotherapy or radiation before surgery, the presence of Rb2 is associated with a higher risk of dying independent
'"/>

Contact: Steve Benowitz
steven.benowitz@mail.tju.edu
215-955-6300
Thomas Jefferson University
26-Feb-1998


Page: 1 2 3

Related biology news :

1. Jefferson Lab detector technology aids development of cystic fibrosis therapy
2. Jefferson scientists find gene expression pattern may predict behavior of leukemia
3. Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue
4. Jefferson scientists use gene therapy to restore function of damaged heart cells in lab
5. Jefferson researchers uncover biochemical clues to how cells migrate in embryos
6. Jefferson and Brigham and Womens researchers find blue light important for setting biological clock
7. Jefferson Lab experiment generates THz radiation 20,000 times brighter than anyone else
8. Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory
9. Jefferson scientists show how collagen gene mutation leads to osteoarthritis
10. Jefferson scientists use gene repair technique to change albino mice hairs to black
11. Jefferson scientists show drug is effective against a Hepatitis C Virus model in the laboratory

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2018)... and CARDIFF, Wales (PRWEB) , ... August 30, ... ... Agency. Martha Sanchez, senior scientist, IBM Research. Jacklyn Novak, infrared materials engineer, LightPath ... Katherine Johnson, the NASA mathematician who just celebrated her 100th birthday. Today, they ...
(Date:8/29/2018)... , ... August 29, 2018 ... ... validates first non-invasive technology to identify specific chromosomal abnormalities using morphological assessment ... Ovation Fertility and Australia-based Life Whisperer suggests that artificial ...
(Date:8/23/2018)... (PRWEB) , ... August 21, 2018 , ... ... the genomes of diverse cell types and species for the robust functional interrogation ... tool for the development of T-cell based immunotherapies, the study of the autoimmunity, ...
Breaking Biology News(10 mins):
(Date:8/23/2018)... ... August 22, 2018 , ... Crucial Data Solutions, Inc. ... it the first fully-featured app for electronic data capture (EDC) and electronic participant ... constitute 99 percent of the market share for mobile devices worldwide; in turn, ...
(Date:8/21/2018)... ... August 21, 2018 , ... The Connecticut Technology Council (CTC) ... of the fastest growing technology companies in Connecticut. This year’s group of top-ranked companies ... October 3, at the Connecticut Convention Center in Hartford. A complete list of the ...
(Date:8/17/2018)... ... August 16, 2018 , ... Ambry Genetics Corporation (“Ambry”), a ... were published today in JAMA Oncology, identifying new and confirming known hereditary breast ... Every year hereditary breast cancer affects more than 20,000 women while hereditary ovarian ...
(Date:8/14/2018)... ... August 14, 2018 , ... Buprenorphine (BUP) is ... BUP is often prescribed as a sublingual co-formulation with the opioid antagonist naloxone ... participants will learn from a review of the pharmacokinetics of BUP, NBP, and ...
Breaking Biology Technology:
Cached News: