Jefferson Researchers Provide Leads To Potential Parkinson's Treatment

A Natural Substance In The Cell Membrane May Either Protect Or Stimulate Brain Cell Activity

A naturally occurring substance in the cell's membrane may improve symptoms in Parkinson's disease patients and perhaps even help slow down the progression of Parkinson's, according to studies by researchers at Jefferson Medical College of Thomas Jefferson University in Philadelphia.

Jay S. Schneider, Ph.D., professor of pathology, cell biology and anatomy and neurology and his co-workers compared a drug, GM1 ganglioside, with a placebo in 45 patients with Parkinson's disease receiving a 16-week course of treatment.

"At the end of the study, test scores in the Unified Parkinson's Disease Rating Scale, which is a standard scale to measure motor abilities, showed a significant difference between those who received the drug and those who did not," says Dr. Schneider. He and his colleagues at Jefferson report their findings in the June issue of the journal Neurology.

The study was a double-blind trial, with neither the researchers nor the patients knowing who receives the drug. GM1 ganglioside is a normal part of the cell membrane that plays an important role in cell growth, development, signal transduction and repair after injury.

According to Dr. Schneider, many of the patients' symptoms, such as rigidity and slow movement, improved during participation in the trial. Patients also reported that they were able to function better in performing daily living activities, such as dressing and handling eating utensils. "Overall, every patient receiving GM1 improved to some degree," he says. "They had less stiffness, less bradykinesia or slowness of movement, and better manual dexterity and motor coordination."

While some participants in the placebo group also slightly improved, the condition of the majority of those who did not receive the drug remained unchanged.

Dr. Schneider and his gr

Contact: Steve Benowitz
Thomas Jefferson University

Page: 1 2 3

Related biology news :

1. Jefferson Lab detector technology aids development of cystic fibrosis therapy
2. Jefferson scientists find gene expression pattern may predict behavior of leukemia
3. Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue
4. Jefferson scientists use gene therapy to restore function of damaged heart cells in lab
5. Jefferson researchers uncover biochemical clues to how cells migrate in embryos
6. Jefferson and Brigham and Womens researchers find blue light important for setting biological clock
7. Jefferson Lab experiment generates THz radiation 20,000 times brighter than anyone else
8. Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory
9. Jefferson scientists show how collagen gene mutation leads to osteoarthritis
10. Jefferson scientists use gene repair technique to change albino mice hairs to black
11. Jefferson scientists show drug is effective against a Hepatitis C Virus model in the laboratory

Post Your Comments:

(Date:9/17/2019)... ... September 17, 2019 , ... Dual-board certified periodontist ... the Australia Society of Implant Dentistry (ASID) Accreditation Courses. His lecture, “Understanding the ... Surgical Aspects of Modern Implant Dentistry course. Dr. Kim’s expertise comes from years ...
(Date:9/8/2019)... Md. (PRWEB) , ... September ... ... biotechnology market disrupter and leading supplier of innovative human mesenchymal stem/stromal cell ... first human umbilical cord (hUC) MSC paired cell and media system designed ...
(Date:8/29/2019)... CARLSBAD, Calif. (PRWEB) , ... ... ... daacro (Diagnostic Assessment and Clinical Research Organization), have recently passed ... combines CRO standards, hormone diagnostics and psychoneuroendocrine stress expertise, with a primary ...
Breaking Biology News(10 mins):
(Date:9/11/2019)... ... September 09, 2019 , ... Tunnell ... government agencies, announced that its president and CEO Maryann Gallivan has been accepted ... , The Forbes Council accepted Gallivan based on the role she and ...
(Date:9/11/2019)... N.J. (PRWEB) , ... September 10, 2019 , ... ... development, and manufacturing solutions for drugs, biologics, gene therapies, and consumer health products, ... Forum, to be held at the Bausparkasse Schwäbisch Hall AG, Schwabisch Hall, Germany, ...
(Date:9/8/2019)... ... 2019 , ... Spartan Bioscience, the leader in on-demand DNA ... has been named Chief Financial Officer. , Spartan has also named former ... Additionally, Spartan has hired Steve Edgett as Executive Vice President to lead international ...
(Date:8/29/2019)... (PRWEB) , ... August 29, 2019 , ... ... chronic disease affecting grapevines, a feat they hope will ultimately help protect the ... Researchers including several Rochester Institute of Technology faculty and alumni sequenced the microbiome ...
Breaking Biology Technology:
Cached News: